The Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control.
The Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control.
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富含碳酸氢盐的矿泉水的消耗可改善血糖控制。
DOI：
10.1155/2015/824395
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fukuda S
中科院分区：
文献类型：
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作者：
Murakami S;Goto Y;Ito K;Hayasaka S;Kurihara S;Soga T;Tomita M;Fukuda S
温泉水和天然矿泉水已被用于治疗，以预防或改善各种疾病。具体而言，据报道，饮用富含碳酸氢盐的矿泉水（BMW）可预防或改善人类2型糖尿病（T2 D）。然而，矿泉水消费背后的有益作用的分子机制仍不清楚。为了阐明BMW消耗对血糖控制的分子水平影响，将血液代谢组分析和粪便微生物组分析应用于BMW消耗测试。在研究期间，19名健康志愿者每天饮用500 mL市售自来水（TW）或BMW。TW消费期和BMW消费期各持续一周，重复两次。生化测试表明，血糖控制指标之一的血清糖蛋白水平，宝马消费后显着下降。血液样本的代谢物组学分析显示，TW和BMW消费期间的19种代谢物（包括糖酵解相关代谢物和3种氨基酸）存在显著差异。此外，微生物组分析表明，在宝马消费后，精益诱导细菌的组成增加。我们的研究结果表明，宝马的消费有可能通过改变宿主代谢和肠道微生物群组成来预防和/或改善T2 D。
Hot spring water and natural mineral water have been therapeutically used to prevent or improve various diseases. Specifically, consumption of bicarbonate-rich mineral water (BMW) has been reported to prevent or improve type 2 diabetes (T2D) in humans. However, the molecular mechanisms of the beneficial effects behind mineral water consumption remain unclear. To elucidate the molecular level effects of BMW consumption on glycemic control, blood metabolome analysis and fecal microbiome analysis were applied to the BMW consumption test. During the study, 19 healthy volunteers drank 500 mL of commercially available tap water (TW) or BMW daily. TW consumption periods and BMW consumption periods lasted for a week each and this cycle was repeated twice. Biochemical tests indicated that serum glycoalbumin levels, one of the indexes of glycemic controls, decreased significantly after BMW consumption. Metabolome analysis of blood samples revealed that 19 metabolites including glycolysis-related metabolites and 3 amino acids were significantly different between TW and BMW consumption periods. Additionally, microbiome analysis demonstrated that composition of lean-inducible bacteria was increased after BMW consumption. Our results suggested that consumption of BMW has the possible potential to prevent and/or improve T2D through the alterations of host metabolism and gut microbiota composition.