Adrenergic ligand liposolubility in membranes. Direct assessment in a beta-adrenergic binding system.
Adrenergic ligand liposolubility in membranes. Direct assessment in a beta-adrenergic binding system.
复制标题
膜中肾上腺素配体的脂溶性。
作者：
E. Dax;J. Partilla
[3 H]二氢烯丙洛尔与脂肪细胞膜的结合不仅可以从β-肾上腺素能受体中置换，还可以通过β-肾上腺素能和其他肾上腺素能药物非立体特异性地从其他膜室中置换。这种非立体特异性可置换结合的EC 50与置换配体的脂溶性（正辛醇：水分配系数）直接相关。
The binding of [3H]dihydroalprenolol to adipocyte membranes may be displaced not only from beta-adrenergic receptors but also nonstereospecifically from other membrane compartments by beta-adrenergic and other adrenergic agents. The EC50 of this nonstereospecific displaceable binding is directly related to the liposolubility (n-octanol:water partition coefficient) of the displacing ligand.