Bootstrap quantification of cardiac pulsation artifact in DTI
Bootstrap quantification of cardiac pulsation artifact in DTI
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DOI：
10.1016/j.neuroimage.2009.06.067
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Henry, Roland G.
中科院分区：
文献类型：
--
作者：
Chung, SungWon;Courcot, Blandine;Henry, Roland G.
虽然有几项研究已经证明了心脏门控在单次激发EPI采集的扩散MRI中的益处，但心脏门控仍然不常用，这可能是因为它需要额外的时间，许多研究者可能不相信心脏门控值得付出额外的努力。在这里，我们测试了一个临床上可行的协议，扫描时间的最小增加，并量化心脏门控的影响下，部分或全部傅立叶采集。8名志愿者在3T扫描仪上使用SENSE 8通道头部线圈进行扫描。沿沿着32个梯度方向采集弥散加权单次自旋回波EPI图像，有或无心脏门控，部分或全部傅立叶采集。使用心电向量描记术（VCG）以最小延迟（30 ms）触发采集。采用残差自举法估计DTI参数的不确定度。利用部分傅立叶，心脏门控降低了不确定性，并且即使允许增加总扫描时间，也实现了降低DTI参数变异性的更好效率。对于全傅立叶采集，最小时间选通略微降低了不确定性，但效率更差。最小触发延迟可能不是避免大部分心脏收缩的最佳方案，但它允许临床上可接受的扫描时间。我们已经证明，心脏门控，特别是部分傅立叶采集，可以减少DTI派生参数的不确定性，在一个时间有效的方式。(C)2009 Elsevier Inc. All rights reserved.
While several studies have shown the benefit of cardiac gating in diffusion MRI with single-shot EPI acquisition, cardiac gating is still not commonly used, This is probably because it requires additional time and many investigators may not be convinced that cardiac gating is worth the extra effort. Here, we tested a clinically feasible protocol with a minimal increase in scan time, and quantified the effect of cardiac gating under partial or full Fourier acquisition. Eight volunteers were scanned on a 3 T scanner with a SENSE 8-channel head coil. Diffusion-weighted, single-shot spin-echo EPI images were acquired along 32 gradient directions, with or without cardiac gating and with partial or full Fourier acquisition. Vectorcardiography (VCG) was used to trigger acquisition at a minimum delay (30 ms). The uncertainties of DTI derived parameters were estimated using residual bootstrap. With partial Fourier, cardiac gating reduced the uncertainties, and better efficiency in reducing DTI parameter variability was also achieved even allowing for the increase in total scan time. For full Fourier acquisition, minimum time gating slightly decreased the uncertainties but the efficiency was worse. A minimum trigger delay might not be the optimal scheme to avoid the majority of systole but it allows clinically acceptable scan times. We have demonstrated that cardiac gating, especially of partial Fourier acquisitions, can reduce the uncertainties of DTI derived parameters in a time-efficient manner. (C) 2009 Elsevier Inc. All rights reserved.