CELL-CYCLE CHECKPOINTS
CELL-CYCLE CHECKPOINTS
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DOI：
10.1016/0955-0674(94)90059-0
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发表时间：
1994-12-01
影响因子：
7.5
通讯作者：
MURRAY, A
中科院分区：
文献类型：
--
作者：
MURRAY, A
检查点有助于确保细胞周期事件以正确的顺序发生。对哺乳动物细胞的研究发现，细胞周期蛋白和细胞周期蛋白依赖性蛋白激酶复合体的抑制剂是细胞周期检查点的组成部分，并首次揭示了阻止DNA受损细胞复制DNA的分子途径。在胚胎中，检查点阻止细胞周期的程度反映了抑制检查点和推动细胞周期向前的机制的相对强度。
Checkpoints help ensure that cell cycle events occur in the correct order. Studies on mammalian cells identified inhibitors of complexes of cyclins and cyclin-dependent kinases as components of cell cycle checkpoints and provide the first glimpse of the molecular pathways that prevent cells with damaged DNA from replicating their DNA. In embryos, the extent to which checkpoints arrest the cell cycle reflects the relative strength of inhibitory checkpoints and the machinery driving the cell cycle forward.