Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging
Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging
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金纳米团簇作为荧光和 X 射线双模态成像的造影剂
DOI：
10.1016/j.jcis.2012.01.005
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发表时间：
2012-04-15
影响因子：
9.9
通讯作者：
Zhang, Bingbo
中科院分区：
文献类型：
--
作者：
Zhang, Aili;Tu, Yu;Zhang, Bingbo
多模态成像技术是提高早期癌症诊断灵敏度的一种替代方法。在这项研究中，高荧光和强X射线吸收系数的金纳米团簇（Au NCs）的合成作为双模态成像造影剂（CA）的荧光和X射线双模态成像。实验结果表明，所制备的Au纳米粒子结构良好，具有超小的尺寸、可靠的荧光发射、高的CT值和良好的生物相容性。体内成像结果表明，所获得的Au NCs能够荧光和X射线增强成像。(C)2012 Elsevier Inc. All rights reserved.
Multimodal imaging technique is an alternative approach to improve sensitivity of early cancer diagnosis. In this study, highly fluorescent and strong X-ray absorption coefficient gold nanoclusters (Au NCs) are synthesized as dual-modality imaging contrast agents (CAs) for fluorescent and X-ray dual-modality imaging. The experimental results show that the as-prepared Au NCs are well constructed with ultrasmall sizes, reliable fluorescent emission, high computed tomography (CT) value and fine biocompatibility. In vivo imaging results indicate that the obtained Au NCs are capable of fluorescent and X-ray enhanced imaging. (C) 2012 Elsevier Inc. All rights reserved.