Gene manipulation and transfer of the plasminogen and coagulation system in mice
Gene manipulation and transfer of the plasminogen and coagulation system in mice
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DOI：
10.1055/s-2007-999055
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发表时间：
1996-01-01
影响因子：
5.7
通讯作者：
Collen, Desire
中科院分区：
文献类型：
--
作者：
Carmeliet, Peter;Collen, Desire
血液凝固和纤维蛋白溶解（或纤溶酶原/纤溶酶）系统决定了血凝块的形成和溶解之间的平衡，但除此之外还有助于各种心血管疾病如血栓形成、动脉粥样硬化和再狭窄的发病机制。此外，它们还参与各种其他（病理）生物学过程，如胚胎发育、生殖、伤口愈合、癌症和脑功能。两个最近开发的技术，基因靶向和基因转移，允许操纵这些蛋白酶系统的遗传平衡在一个可控的方式允许更明确的阐明这些系统的生物学作用。本文综述了基因靶向研究的进展，并讨论了利用腺病毒介导的纤溶基因转移来研究和开发新的治疗再狭窄和血栓形成的策略。
The blood coagulation and the fibrinolytic (or plasminogen/plasmin) systems determine the balance between the formation and dissolution of blood clots, but in addition contribute to the pathogenesis of various cardiovascular disorders such as thrombosis, atherosclerosis, and restenosis. Furthermore, they participate in a variety of other (patho)-biological processes such as embryonic development, reproduction, wound healing, cancer, and brain function. Two recently developed technologies, gene targeting and gene transfer, that allow manipulation of the genetic balance of these proteinase systems in a controllable manner have allowed a more definitive elucidation of the biological role of these systems. This review summarizes the insights that have been obtained from the gene targeting studies and discusses the use of adenovirus-mediated transfer of fibrinolytic genes to study and possibly to develop novel strategies for the treatment of restenosis and thrombosis.