Ultrasound-guided contrast-enhanced sentinel node biopsy of the head and neck in a porcine model
Ultrasound-guided contrast-enhanced sentinel node biopsy of the head and neck in a porcine model
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DOI：
10.1016/j.otohns.2007.07.019
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发表时间：
2007-11-01
影响因子：
3.4
通讯作者：
Pribitkin, Edmund A.
中科院分区：
文献类型：
--
作者：
Curry, Joseph M.;Bloedon, Esa;Pribitkin, Edmund A.
目的：为了测试的可行性，对比增强超声（CEUS）引导前哨淋巴结活检（SNB）的头部和颈部在猪model.Study设计和设置：在这个前瞻性的，非随机研究，亚甲蓝和Sonazoid注射到舌侧或口底（FOM）的四只猪。实时CEUS用于识别流向前哨淋巴结（SLN）的淋巴通道中的造影剂。进行了内镜或开放SNB。然后进行颈淋巴结清扫术，并检查剩余的对比增强或蓝色染料染色nodes.RESULTS：在所有8个程序，SLN可视化与超声和蓝色染料的残留的淋巴结包。7例手术确定了1个SLN，1例确定了2个SLN。随后的颈部解剖发现没有其他节点含有亚甲蓝或对比剂的节点标本或operating bed.CONCLUSION /SIGNIFICANCE：CEUS引导SNB的头部和颈部的猪是可行的，与成功的蓝色染料引导SNB。这种技术可能比传统技术提供几个优点，并值得进一步研究。(C)2007年美国耳鼻咽喉头颈外科学会基金会。All rights reserved.
OBJECTIVE: To test the feasibility of contrast-enhanced ultrasound (CEUS)-guided sentinel lymph node biopsy (SNB) of the head and neck in a porcine model.STUDY DESIGN AND SETTING: In this prospective, non-randomized study, methylene blue and Sonazoid were injected into the lateral tongue or floor of mouth (FOM) of four swine. Real-time CEUS was used to identify contrast in the lymphatic channels flowing to the sentinel lymph node (SLN). Endoscopic or open SNB was performed. Neck dissection was then performed, and the residual nodal packet was examined for remaining contrast-enhancing or blue dye-stained nodes.RESULTS: In all eight procedures, the SLN was visualized with ultrasound and blue dye. Seven procedures identified a single SLN, and one identified two SLNs. Subsequent neck dissections revealed no other nodes containing methylene blue or contrast in the nodal specimen or operative bed.CONCLUSION /SIGNIFICANCE: CEUS-guided SNB of the head and neck in swine is feasible, with success comparable to blue dye-guided SNB. This technique may offer several advantages over traditional techniques, and warrants further study.(C) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.