Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model.
Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model.
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DOI：
10.1371/journal.pone.0160882
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Hoffman RM
中科院分区：
文献类型：
--
作者：
Yamamoto M;Zhao M;Hiroshima Y;Zhang Y;Shurell E;Eilber FC;Bouvet M;Noda M;Hoffman RM
肿瘤靶向性肠炎沙门氏菌A1-R(沙门氏菌A1-R)对黑色素瘤患者来源的原位异种移植(PDOX)裸鼠模型有很强的疗效。表达绿色荧光蛋白的沙门氏菌A1-R高选择性地在PDOX黑色素瘤中定植，并显著抑制肿瘤生长(p=0.021)。低剂量的沙门氏菌A1-R和顺铂(CDDP)联合应用也显著抑制了黑色素瘤细胞的生长(P=0.001)。沙门氏菌A1-R具有与顺铂联合化疗治疗黑色素瘤的未来临床潜力，黑色素瘤是一种高度顽固性癌症。
Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0.021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.