GM-CSF: A Promising Target in Inflammation and Autoimmunity.
GM-CSF: A Promising Target in Inflammation and Autoimmunity.
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DOI：
10.2147/itt.s262566
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发表时间：
2020
影响因子：
7.2
通讯作者：
Hamilton JA
中科院分区：
文献类型：
--
作者：
Lee KMC;Achuthan AA;Hamilton JA
细胞因子粒细胞巨噬集落刺激因子（GM-CSF）首次被发现能够在体外诱导骨髓祖细胞向粒细胞和巨噬细胞的增殖和分化。许多临床前数据表明，GM-CSF对骨髓细胞的作用在不同组织中具有广泛的功能，并且GM-CSF缺失/耗尽方法表明其作为几种炎症和自身免疫性疾病（例如类风湿性关节炎）的重要治疗靶点的潜力。在这篇综述中，我们简要讨论了GM-CSF的生物学特性，提出了与该生物学相关的一些当前问题和问题，总结了一系列炎症和自身免疫性疾病的临床前模型的结果，并列出了评估GM-CSF阻断在这些疾病中的最新临床试验。
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro the proliferation and differentiation of bone marrow progenitors into granulocytes and macrophages. Much preclinical data have indicated that GM-CSF has a wide range of functions across different tissues in its action on myeloid cells, and GM-CSF deletion/depletion approaches indicate its potential as an important therapeutic target in several inflammatory and autoimmune disorders, for example, rheumatoid arthritis. In this review, we discuss briefly the biology of GM-CSF, raise some current issues and questions pertaining to this biology, summarize the results from preclinical models of a range of inflammatory and autoimmune disorders and list the latest clinical trials evaluating GM-CSF blockade in such disorders.