Long non-coding RNA Linc00320 inhibits glioma cell proliferation through restraining Wnt/β-catenin signaling
Long non-coding RNA Linc00320 inhibits glioma cell proliferation through restraining Wnt/β-catenin signaling
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长非编码 RNA Linc00320 通过抑制 Wnt/β-catenin 信号传导抑制胶质瘤细胞增殖
DOI：
10.1016/j.bbrc.2018.11.101
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发表时间：
2019-01-08
影响因子：
3.1
通讯作者：
Zhan, Shikun
中科院分区：
文献类型：
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作者：
Tian, Shuaiwei;Liu, Wei;Zhan, Shikun
近年来的研究发现，大量的致癌lncRNA在胶质瘤的发生发展中起着重要作用，而抑癌lncRNA在胶质瘤中的作用却知之甚少。在本研究中，我们发现HMGB 1调控的IncRNA Linc 00320在胶质瘤恶性组织中显著减少，其低表达预示预后不良。此外，我们发现，核定位的Linc 00320抑制胶质瘤细胞增殖在体外和体内。此外，我们发现Linc 00320与β-catenin结合，并通过破坏β-catenin与胶质瘤细胞中TCF 4的结合来抑制Wnt/β-catenin信号传导的活性。综上所述，我们首次证明了肿瘤抑制性lncRNA Linc 00320在胶质瘤组织中下调，并通过分离β-catenin和TCF 4抑制Wnt/β-catenin信号传导来抑制胶质瘤细胞增殖，并揭示了胶质瘤进展中新的HMGB 1/Linc 00320/β-catenin轴。(C)2018爱思唯尔公司All rights reserved.
Recent efforts have revealed that numerous oncogenic lncRNAs have been found play pivotal role in Glioma progression while there is little know about anti-oncogenic lncRNAs in Glioma. In current study, we found a HMGB1 regulated IncRNA, Linc00320, is significantly decreased in Glioma malignant tissues and its low expression predicts poor prognosis. Moreover, we found that the nucleus localized Linc00320 inhibits Glioma cell proliferation both in vitro and in vivo. In addition, we found that Linc00320 binds to beta-catenin and inhibits the activity of Wnt/beta-catenin signaling by disrupting beta-catenin binds to TCF4 in Glioma cells. Taken together, we firstly demonstrated the tumor suppressive lncRNA, Linc00320, is down-regulated in Glioma tissues and inhibits Glioma cell proliferation by restraining Wnt/beta-catenin signaling through segregating beta-catenin and TCF4 and revealed the novel HMGB1/Linc00320/beta-catenin axis in Glioma progression. (C) 2018 Elsevier Inc. All rights reserved.