Epigenetic dynamics in infancy and the impact of maternal engagement
Epigenetic dynamics in infancy and the impact of maternal engagement
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DOI：
10.1126/sciadv.aay0680
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发表时间：
2019-10-01
期刊：
影响因子：
13.6
通讯作者：
Connelly, Jessica J.
中科院分区：
文献类型：
--
作者：
Krol, Kathleen M.;Moulder, Robert G.;Connelly, Jessica J.
先天与后天对人类行为发展的影响已经争论了几个世纪。在这里，我们通过确定人类内源性催产素系统——已知其在哺乳动物社会中的关键作用——作为一个对早期环境敏感并受表观遗传变化影响的系统，为这个复杂的谜题提供了一个线索。最近的动物研究表明，早期亲代养育与催产素受体基因（OXTRm）中保守调控位点的DNA甲基化变化有关。通过第一年半的行为和OXTRm状态的二元模型，我们将这些发现转化为101对人类母婴。研究表明，婴儿期的OXTRm是动态的，其变化可以通过母亲的参与和行为气质的反映来预测。我们为催产素系统的环境表观遗传调控的早期窗口提供了证据，促进了人类行为个体差异的出现。
The contribution of nature versus nurture to the development of human behavior has been debated for centuries. Here, we offer a piece to this complex puzzle by identifying the human endogenous oxytocin system-known for its critical role in mammalian sociality-as a system sensitive to its early environment and subject to epigenetic change. Recent animal work suggests that early parental care is associated with changes in DNA methylation of conserved regulatory sites within the oxytocin receptor gene (OXTRm). Through dyadic modeling of behavior and OXTRm status across the first year and a half of life, we translated these findings to 101 human mother-infant dyads. We show that OXTRm is dynamic in infancy and its change is predicted by maternal engagement and reflective of behavioral temperament. We provide evidence for an early window of environmental epigenetic regulation of the oxytocin system, facilitating the emergence of individual differences in human behavior.