SRC-3 has a role in cancer other than as a nuclear receptor coactivator.
SRC-3 has a role in cancer other than as a nuclear receptor coactivator.
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DOI：
10.7150/ijbs.7.664
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发表时间：
2011
影响因子：
9.2
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Ma G;Ren Y;Wang K;He J
类固醇受体辅激活因子-3（SRC-3），也称为AIB 1，是p160类固醇受体辅激活因子家族的成员。自1997年发现SRC-3在乳腺癌中扩增以来，SRC-3在癌症中的作用已被广泛研究。SRC-3最初被鉴定为核受体（如雌激素受体（ER））的转录共激活因子，其参与了雌激素依赖性癌症的增殖。然而，越来越多的临床证据表明，SRC-3在几种人类非肿瘤依赖性癌症中的表达失调与病理因素和临床预后相关。最近，在体内和体外研究表明，SRC-3可能会影响一些癌症细胞过程中的几种方式独立于核受体信号。此外，SRC-3转基因小鼠模型显示SRC-3在几种小鼠组织中诱导肿瘤。这些结果表明SRC-3在癌症中的作用不仅仅是作为核受体辅激活剂。这篇综述的重点是研究SRC-3在癌症中可能的作用，而不是作为核受体辅激活剂。
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family. Since SRC-3 was found to be amplified in breast cancer in 1997, the role of SRC-3 in cancer has been broadly investigated. SRC-3 initially was identified as a transcriptional coactivator for nuclear receptors such as the estrogen receptor (ER), involved in the proliferation of hormone-dependent cancers. However, increasing clinical evidence shows that dysregulation of SRC-3 expression in several human hormone-independent cancers is correlated with pathological factors and clinical prognosis. Recently, both in vivo and in vitro studies demonstrate that SRC-3 may influence a number of cancer cellular processes in several ways independent of nuclear receptor signaling. In addition, an SRC-3 transgenic mice model shows that SRC-3 induces tumors in several mouse tissues. These results indicate that the role of SRC-3 in cancer is not just as a nuclear receptor coactivator. The focus of this review is to examine possible SRC-3 roles in cancer, other than as a nuclear receptor coactivator.
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