Hypothalamic regulation of cortical bone mass: Opposing activity of Y2 receptor and leptin pathways
Hypothalamic regulation of cortical bone mass: Opposing activity of Y2 receptor and leptin pathways
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DOI：
10.1359/jbmr.060705
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发表时间：
2006-10-01
影响因子：
6.2
通讯作者：
Herzog, Herbert
中科院分区：
文献类型：
--
作者：
Baldock, Paul A.;Allison, Susan;Herzog, Herbert
神经肽Y-、Y2受体(Y2)-和瘦素缺陷小鼠在松质骨中表现出类似的合成代谢作用，但在皮质骨中尚未得到评估。Y2(-/-)小鼠的皮质骨量通过更大的成骨细胞活动而增加。相比之下，瘦素缺乏会导致骨量减少。我们发现皮质骨的中枢调节是相反的。
NeuropeptideY-, Y2 receptor (Y2)-, and leptin-deficient mice show similar anabolic action in cancellous bone but have not been assessed in cortical bone. Cortical bone mass is elevated in Y2(-/-) mice through greater osteoblast activity. In contrast, leptin deficiency results in reduced bone mass. We show opposing central regulation of cortical bone.