Green tea extract and catechol-O-methyltransferase genotype modify the post-prandial serum insulin response in a randomised trial of overweight and obese post-menopausal women.
Green tea extract and catechol-O-methyltransferase genotype modify the post-prandial serum insulin response in a randomised trial of overweight and obese post-menopausal women.
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DOI：
10.1111/jhn.12408
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发表时间：
2017-04
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影响因子：
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通讯作者：
Stendell-Hollis NR
中科院分区：
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作者：
Dostal AM;Arikawa A;Espejo L;Bedell S;Kurzer MS;Stendell-Hollis NR
绿色茶提取物（GTE）可能参与对高碳水化合物膳食的有利餐后反应。儿茶酚-O-甲基转移酶（COMT）基因型可能会改变这些影响。我们通过评估食用843 mg（−）-表没食子儿茶素-3-没食子酸酯（EGCG）或安慰剂胶囊11-12个月的女性的食欲相关激素和葡萄糖稳态标志物浓度，研究了GTE补充剂对高碳水化合物餐后反应的急性影响。60名绝经后白人女性（BMI ≥ 25.0 kg/m2）被纳入一项随机、双盲喂养研究。GTE与早餐一起摄入（665.4 kcal; 67.2%碳水化合物）。在餐前、餐后和每30分钟采集一次血样，持续4 h。参与者完成了六份饱腹感问卷。GTE组和安慰剂组在任何时间点的血浆瘦素、生长激素释放肽和脂联素均无差异; COMT基因型并不改变这些结果。与随机分配至安慰剂组的所有COMT组相比，随机分配至GTE高活性形式COMT（GTE高COMT）组的受试者在餐后0、0.5和1.0 h时的胰岛素浓度较高。与安慰剂低COMT组相比，GTE高COMT组在1.5、2.0和2.5小时的胰岛素仍然较高（P < 0.02）。与GTE-低COMT相比，GTE-高COMT在时间0、0.5、1.0、1.5和2.0 h的胰岛素浓度更高（P ≤ 0.04）。饱腹感的AUC测量值在GTE和安慰剂之间没有差异。补充GTE和COMT基因型并没有改变瘦素、生长激素释放肽、脂联素或饱腹感的急性餐后反应，但可能参与超重和肥胖绝经后妇女的餐后胰岛素血症反应。
Green tea extract (GTE) may be involved in a favorable postprandial response to high-carbohydrate meals. Catechol-O-methyltransferase (COMT) genotype may modify these effects. We examined the acute effects of GTE supplementation on postprandial response to a high-carbohydrate meal through assessing appetite-associated hormones and glucose homeostasis marker concentrations in women who consumed 843 mg (−)-epigallocatechin-3-gallate [EGCG]) or placebo capsules for 11-12 months. Sixty Caucasian postmenopausal women (BMI ≥ 25.0 kg/m2) were included in a randomized, double-blind feeding study. GTE was consumed with a breakfast meal (665.4 kcal; 67.2% carbohydrate). Blood samples were drawn pre-meal, post-meal, and every 30 minutes for 4 h. Participants completed six satiety questionnaires. Plasma leptin, ghrelin, and adiponectin did not differ between GTE and placebo at any time point; COMT genotype did not modify these results. Participants randomized to GTE with the high-activity form of COMT (GTE-high COMT) had higher insulin concentrations at time 0, 0.5, and 1.0 h post-meal compared to all COMT groups randomized to placebo. Insulin remained higher in the GTE-high COMT group at 1.5, 2.0, and 2.5 h compared to Placebo-low COMT (P < 0.02). GTE-high COMT had higher insulin concentrations at times 0, 0.5, 1.0, 1.5, and 2.0 h compared to the GTE-low COMT (P ≤ 0.04). AUC measurements of satiety did not differ between GTE and placebo. GTE supplementation and COMT genotype did not alter acute postprandial responses of leptin, ghrelin, adiponectin, or satiety, but may be involved in post-meal insulinemic response of overweight and obese postmenopausal women.