Dissecting the Role of Disturbed ER-Golgi Trafficking in Antivirals and Alcohol Abuse-Induced Pathogenesis of Liver Disorders.
Dissecting the Role of Disturbed ER-Golgi Trafficking in Antivirals and Alcohol Abuse-Induced Pathogenesis of Liver Disorders.
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DOI：
10.21767/2471-853x.100054
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Ji, Cheng
中科院分区：
文献类型：
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作者：
Ji, Cheng
抗病毒药物和酒精滥用诱导的细胞器应激与许多疾病有关，其潜在的分子机制正在深入研究中。这篇简短的综述传达了关于某些抗病毒药物和酒精如何影响内质网高尔基体运输的新证据和研究趋势，这可能会影响高尔基体的功能和完整性，从而导致内质网应激和细胞损伤。
Antiviral drugs and alcohol abuse-induced organelle stresses have been linked to many disorders and the underlying molecular mechanisms are under intense investigations. This brief review communicates emerging evidence and research trends on how certain antivirals and alcohol affect ER-Golgi trafficking, which potentially impacts the function and integrity of the Golgi apparatus contributing to endoplasmic reticulum stress and cellular injury.