Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer
Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer
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DOI：
10.1097/01.ajp.0000210902.67849.e6
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发表时间：
2006-09-01
影响因子：
2.9
通讯作者：
Mantyh, Patrick W.
中科院分区：
文献类型：
--
作者：
Halvorson, Kyle G.;Sevcik, Molly A.;Mantyh, Patrick W.
仅在2006年，美国就将有超过130万例癌症被确诊，而且90%的晚期癌症患者将经历由癌症引发的严重的、改变生活的疼痛。骨癌疼痛是晚期癌症患者中最常见的疼痛，因为包括乳腺、前列腺和肺部在内的大多数常见肿瘤都极易转移到骨骼。一旦肿瘤转移到骨骼，它们就会成为发病和死亡的主要原因，因为肿瘤会引发显著的骨骼重塑、疼痛和贫血，这会降低患者的生存率和生活质量。目前，人们对引发癌症疼痛的因素了解甚少；然而，最近引入的几种癌症疼痛模型不仅让人们深入了解了引发骨癌疼痛的机制，还指导了基于新机制的疗法的开发，以治疗转移性骨癌伴随的疼痛和骨骼重塑。由于镇痛药也会影响疾病进展，这些研究的结果可能会催生一些疗法，这些疗法有可能改善骨骼恶性肿瘤患者的生活质量和生存率。
More than 1.3 million cases of cancer will be diagnosed in 2006 in the United States alone, and 90% of patients with advanced cancer will experience significant, life-altering cancer-induced pain. Bone cancer pain is the most common pain in patients with advanced cancer as most common tumors including breast, prostate, and lung have a remarkable affinity to metastasize to bone. Once tumors metastasize to bone they are a major cause of morbidity and mortality as the tumor induces significant skeletal remodeling, pain and anemia, which reduce the survival and quality of life of the patient. Currently, the factors that drive cancer pain are poorly understood; however, several recently introduced models of cancer pain are not only providing insight into the mechanisms that drive bone cancer pain but are guiding the development of novel mechanism-based therapies to treat the pain and skeletal remodeling that accompanies metatstatic bone cancer. As analgesics can also influence disease progression, findings from these studies may lead to therapies that have the potential to improve the quality of life and survival of patients with skeletal malignancies.