Exercise induces angiogenesis but does not alter movement representations within rat motor cortex
Exercise induces angiogenesis but does not alter movement representations within rat motor cortex
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DOI：
10.1016/s0006-8993(02)02239-4
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发表时间：
2002-04-26
期刊：
影响因子：
2.9
通讯作者：
VandenBerg, PA
中科院分区：
文献类型：
--
作者：
Kleim, JA;Cooper, NR;VandenBerg, PA
研究了运动对大鼠前肢运动皮层运动表征和血管密度的影响。成年雄性大鼠被分配到自愿锻炼（VX）或非活动条件（IC）。VX动物饲养30天，不受限制地使用转轮，而IC动物饲养在标准实验室笼中。VX动物每天行走的距离逐渐增加，在30天的训练期间平均跑58.3公里。微电极刺激被用来获得高分辨率地图的前肢表示在运动皮层的动物从这两种条件。VX和IC动物之间的远端（手腕/手指）或近端（肘/肩）运动表征区域无显著差异。然而，VX动物的前肢运动皮层V层内的血管密度明显更大。这些结果表明，增加前肢运动活动足以诱导皮质血管生成不改变前肢运动皮层内的前肢运动表示的地形。(C)出版社：Elsevier Science B. V.
The effects of exercise on the topography of movement representations and blood vessel density within the rat forelimb motor cortex was examined. Adult male rats were allocated to either a Voluntary eXercise (VX) or Inactive Condition (IC). VX animals were housed for 30 days with unlimited access to running wheels while IC animals were housed in standard laboratory cages. VX animals exhibited a progressive increase in the distance traveled per day and ran an average of 58.3 km across the 30-day training period. Microelectrode stimulation was used to derive high resolution maps of the forelimb representations within the motor cortex of animals from both conditions. No significant differences in the area of either distal (wrist/digit) or proximal (elbow/shoulder) movement representations were found between VX and IC animals. However, VX animals did have a significantly greater density of blood vessels within layer V of the forelimb motor cortex. These results demonstrate that increases in forelimb motor activity sufficient to induce cortical angiogenesis does not alter the topography of forelimb movement representations within forelimb motor cortex. (C) 2002 Published by Elsevier Science B.V.