STEM CELL APPLICATIONS IN INTERVERTEBRAL DISC REPAIR
STEM CELL APPLICATIONS IN INTERVERTEBRAL DISC REPAIR
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DOI：
10.1170/t827
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发表时间：
2008-01-01
影响因子：
1.6
通讯作者：
Sakai, D.
中科院分区：
文献类型：
--
作者：
Hiyama, A.;Mochida, J.;Sakai, D.
干细胞治疗的兴趣日益增加，因为它为治疗各种疾病提供了新的选择。目前正在探索几种实验方法，以使用干细胞延缓或逆转椎间盘的退行性过程，椎间盘是腰痛的主要原因。在这篇文章中，我们回顾了目前的策略，干细胞应用于椎间盘修复，并提出了三个新的方法。这些是，第一，通过与间充质干细胞共培养激活髓核细胞用于自体椎间盘细胞再植入;第二，从间充质干细胞体外诱导髓核样或纤维环样细胞;第三，通过将间充质干细胞直接移植到实验诱导退变的椎间盘的体内诱导研究。虽然尚未经过测试，但干细胞疗法可能成为治疗椎间盘退变的主要选择。
There is increasing rise of interest in stem cell therapy, as it provides new options for treating a broad range of diseases. Several experimental methods are being explored for the use of stem cells in delaying or reversing the degenerative process of the intervertebral disc, a major cause of low back pain. In this article, we review the current strategies for stem cell applications in intervertebral disc repair and present three novel approaches. These are, first, the activation of nucleus pulposus cells by co-culture with mesenchymal stem cells for autologous disc cell reinsertion; second, the in vitro induction of nucleus pulposus-like or annulus fibrosus-like cells from mesenchymal stem cells; and third, the in vivo induction study by direct transplantation of mesenchymal stem cells to the intervertebral disc induced to degenerate experimentally. Although still untested, stem cell therapy may become a major option in the treatment of intervertebral disc degeneration.