A phenomenological model for mechanically mediated growth, remodeling, damage, and plasticity of gel-derived tissue engineered blood vessels.
A phenomenological model for mechanically mediated growth, remodeling, damage, and plasticity of gel-derived tissue engineered blood vessels.
复制标题
用于机械介导的凝胶衍生组织工程血管的生长、重塑、损伤和可塑性的现象学模型。
DOI：
10.1115/1.4000124
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
GleasonJr,RudolphL
中科院分区：
文献类型：
--
作者：
Raykin,Julia;Rachev,AlexanderI;GleasonJr,RudolphL
机械刺激已被证明可以显着改善凝胶衍生的组织工程血管（TEBV）的机械和功能特性。调节因素，如细胞来源，细胞外基质的类型，交联，幅度，频率和机械刺激的时间过程（在许多其他因素中），使实验结果的解释具有挑战性。解释此类多因素实验的数据需要建模。我们提出了一个建模框架和模拟机械介导的增长，重塑，可塑性和损伤的凝胶衍生的TEBV合并的想法，从经典的可塑性，体积增长，和连续损伤力学。我们的研究结果与已发表的数据进行了比较，并建议该模型框架可以预测的几何形状和材料的行为下常见的实验加载方案的演变。
Mechanical stimulation has been shown to dramatically improve mechanical and functional properties of gel-derived tissue engineered blood vessels (TEBVs). Adjusting factors such as cell source, type of extracellular matrix, cross-linking, magnitude, frequency, and time course of mechanical stimuli (among many other factors) make interpretation of experimental results challenging. Interpretation of data from such multifactor experiments requires modeling. We present a modeling framework and simulations for mechanically mediated growth, remodeling, plasticity, and damage of gel-derived TEBVs that merge ideas from classical plasticity, volumetric growth, and continuum damage mechanics. Our results are compared with published data and suggest that this model framework can predict the evolution of geometry and material behavior under common experimental loading scenarios.