The activity of cerebellar neurones of the decerebrate dogfish Scyliorhinus during spontaneous swimming movements.
The activity of cerebellar neurones of the decerebrate dogfish Scyliorhinus during spontaneous swimming movements.
复制标题
去大脑角鲨 Scyliorhinus 在自发游泳运动期间小脑神经元的活动。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
B. L. Roberts
中科院分区：
文献类型：
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作者：
D. H. Paul;B. L. Roberts
使用微电极检查去大脑角鲨（Scyliorhinus canicula）中小脑神经元响应皮肤刺激和自发的游泳样运动的活动模式。在菱形脑内内侧纵束（m.l.f.）受损的鱼中获得了持续数小时的连续游泳运动。观察到浦肯野细胞（P 细胞）和一些星状细胞（S 细胞）有节奏地放电，与游泳运动同步。这些单位分布在整个小脑，但没有明显的体位分布。箭毒化后，仍可从腹侧记录节律性运动放电，并从小脑记录锁相 P 细胞放电。 P细胞在主动游泳运动期间有节奏地放电，但当身体在静止期间被动振荡时则不会这样做。在箭毒化之前和之后，无论是否产生节律性运动输出，皮肤刺激都会在长潜伏期（约 100 毫秒）内引起许多 P 细胞的爆发放电。在有节奏的放电单元中，当在单元最活跃或最不活跃的周期部分期间施加皮肤刺激时，获得了类似的响应。结论是，小脑神经元的放电与脊髓运动节律发生器的输出同相，并且独立于周围感觉反馈。
Patterns of activity of cerebellar neurones in response to cutaneous stimulation and during spontaneous, swimming‐like movements were examined, using microelectrodes, in decerebrate dogfish (Scyliorhinus canicula). Continuous swimming movements, lasting for several hours, were obtained in fish in which the medial longitudinal fasciculus (m.l.f.) was lesioned in the rhombencephalon. Purkinje cells (P cells) and some stellate cells (S cells) were observed to discharge rhythmically, in phase with swimming movements. These units were distributed throughout the cerebellum, but with no apparent somatotopic distribution. After curarization, rhythmic motor discharges could still be recorded from ventral roots and phase locked P cell discharges were recorded from the cerebellum. P cells that discharged rhythmically during active swimming movements, did not do so when the body was oscillated passively during quiescent periods. Cutaneous stimulation evoked burst discharges in many P cells at long latency (ca. 100 ms) both before and after curarization and whether or not a rhythmic motor output was being generated. In rhythmically discharging units, a similar response was obtained when cutaneous stimulation was applied during that part of a cycle when the unit was most or least active. It was concluded that cerebellar neurones discharged in phase with the output of the spinal locomotory rhythm generators and independently of peripheral sensory feed‐back.