Middle ear cholesteatoma
Middle ear cholesteatoma
复制标题
中耳胆脂瘤
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
H. Sudhoff
中科院分区：
文献类型：
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作者：
Jürgen;H. Sudhoff
胆脂瘤可起源于颞骨的不同部位，颞骨是中耳和其他结构的所在地。胆脂瘤分为三种类型：耳道、中耳和岩尖。最常见的类型是中耳胆脂瘤，可分为先天性和后天两种。关于这种侵袭性中耳炎症的病因学已经提出了许多理论，在某些情况下，又被驳回了。我们研究了细菌感染在胆脂瘤发展中的触发作用。为此，我们使用现代分子、细胞生物学和免疫组织化学方法处理人类活检材料，因为迄今为止还不可能建立类似人类胆脂瘤的动物模型。我们报告了关于胆脂瘤的起源和发展的不同理论，以及支持这些假设的研究结果。许多关于过度增生的研究，胆脂瘤的各种形态切片，以及这些区域不同蛋白质的表达，完成了我们工作的介绍。最后，我们强调，有证据表明，人类外耳皮肤先天抗菌防御系统的弱点可能在胆脂瘤的发展中起决定性作用。
Cholesteatomas can originate at various sites on the temporal bone, which houses the middle ear among other structures. Distinction is made between three types of cholesteatoma: auditory canal, middle ear, and petrous apex. The most frequent type, middle ear cholesteatoma, can be subdivided into a congenital and an acquired form. A number of theories on the aetiology of this aggressive form of middle ear inflammation have been put forward and, in some cases, dismissed again.We investigated the role of bacterial infection as a trigger in the development of cholesteatomas. For this purpose, we used modern molecular, cellular biological and immunohistochemical approaches on human biopsy material, since it has not been possible to date to establish an animal model resembling the human cholesteatoma. We report the different theories on the origin and development of cholesteatomas, as well as the findings to support each of these hypotheses. Many investigations into hyperproliferation, the various morphological sections of cholesteatomas, as well as into the expression of different proteins in these areas complete the presentation of our work. Finally, we emphasize that there is evidence to indicate that a weakness in the innate antimicrobial defense system of the human external ear skin may make a decisive contribution in the development cholesteatomas.
中耳胆脂瘤的血管生成和血管生成生长因子。
DOI：
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发表时间：
2000
期刊：
The American journal of otology
影响因子：
--
作者：
Sudhoff,H;Dazert,S;Gonzales,AM;Borkowski,G;Park,SY;Baird,A;Hildmann,H;Ryan,AF
通讯作者：
Ryan,AF