Effects of Aliskiren-Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients
Effects of Aliskiren-Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients
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DOI：
10.1111/j.1751-7176.2012.00640.x
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发表时间：
2012-08-01
影响因子：
2.8
通讯作者：
Umemura, Satoshi
中科院分区：
文献类型：
--
作者：
Kanaoka, Tomohiko;Tamura, Kouichi;Umemura, Satoshi
临床高血压杂志（格林威治）。2012年;00：000000。(c)2012年威利期刊公司阿利吉仑是一种直接的肾素抑制剂，在肾素-血管紧张素系统的限速步骤发挥其作用。本研究旨在检查阿利吉仑为基础的抗高血压治疗对未经治疗的日本轻度至中度高血压患者的动态血压（BP）特征、中心性血流动力学和动脉僵硬度的有益影响。21名患有未经治疗的轻度至中度原发性高血压的日本非糖尿病患者最初接受阿利吉仑150 mg每日一次给药，根据需要将剂量滴定至300 mg。阿利吉仑治疗12周后，门诊、门诊和中心血压值以及臂踝脉搏波速度（baPWV）均较基线显著降低（门诊收缩压，151 +/- 11 mm Hg vs 132 +/- 11 mm Hg;门诊舒张压，91 +/- 13 mm Hg vs 82 +/- 9 mm Hg; 24小时收缩压，144 +/- 12 mm Hg vs 133 +/- 11 mm Hg; 24小时舒张压，88 +/- 8 mm Hg vs 81 +/- 9 mm Hg;中心压，162 +/- 16 mm Hg vs 148 +/- 14 mm Hg; baPWV，1625 +/- 245 cm/s vs 1495 +/- 199 cm/s; P
J Clin Hypertens (Greenwich). 2012;00:000000. (c) 2012 Wiley Periodicals, Inc. Aliskiren is a direct renin inhibitor that exerts its effect at the rate-limiting step of the renin-angiotensin system. This study was performed to examine the beneficial effects of aliskiren-based antihypertensive therapy on the ambulatory blood pressure (BP) profile, central hemodybamics, and arterial stiffness in untreated Japanese patients with mild to moderate hypertension. Twenty-one Japanese nondiabetic patients with untreated mild to moderate essential hypertension were initially given aliskiren once daily at 150 mg, and the dose was titrated up to 300 mg as needed. After 12 weeks of aliskiren-based therapy, the clinic, ambulatory, and central BP values as well as brachial-ankle pulse wave velocity (baPWV) were all significantly decreased compared with baseline (clinic systolic BP, 151 +/- 11 mm Hg vs 132 +/- 11 mm Hg; clinic diastolic BP, 91 +/- 13 mm Hg vs 82 +/- 9 mm Hg; 24-hour systolic BP, 144 +/- 12 mm Hg vs 133 +/- 11 mm Hg; 24-hour diastolic BP, 88 +/- 8 mm Hg vs 81 +/- 9 mm Hg; central BP, 162 +/- 16 mm Hg vs 148 +/- 14 mm Hg; baPWV, 1625 +/- 245 cm/s vs 1495 +/- 199 cm/s; P