HIV WASTING SYNDROME IN THE UNITED-STATES
HIV WASTING SYNDROME IN THE UNITED-STATES
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DOI：
10.1097/00002030-199302000-00005
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发表时间：
1993-02-01
期刊：
影响因子：
3.8
通讯作者：
RULLAN, JV
中科院分区：
文献类型：
--
作者：
NAHLEN, BL;CHU, SY;RULLAN, JV
目的：描述美国和美国境内年龄大于或等于13岁的HIV耗竭综合征患者的特征。设计：回顾全国艾滋病病例监测资料。方法：回顾1987年9月1日至1991年8月31日向美国疾病控制中心报告的147 225例艾滋病患者的资料。结果：10525例(7.1%)患者中，10525例(7.1%)以消瘦综合征为唯一的艾滋病标志性疾病，15726例(10.7%)合并至少一种其他艾滋病标志性疾病。将虚弱综合征作为唯一艾滋病诊断的患者更有可能是女性，黑人或西班牙裔，并有艾滋病毒接触方式的报告，如注射毒品，异性接触，或输血/血友病。报告患有消瘦综合症的艾滋病患者的比例因地理分布而异，从美国东北部的11%到波多黎各的47%不等。艾滋病毒消耗综合征与西班牙裔族裔之间的联系是由于波多黎各艾滋病患者报告的消耗综合征的患病率要高得多。与消瘦综合征关系最密切的其他艾滋病指标疾病是等孢子虫病、肺部念珠菌病、食道念珠菌病、HIV脑病、慢性皮肤粘膜单纯疱疹和球孢子菌病。结论：HIV消瘦综合征与注射吸毒之间的关联，以及这种艾滋病诊断患病率的显著种族/民族和地理差异，可能反映了诊断和报告做法和/或获得医疗保健的差异。
Objective: To describe the characteristics of individuals greater-than-or-equal-to 13 years of age with HIV wasting syndrome in the United States and US territories.Design: Retrospective review of national AIDS case surveillance data.Methods: Data for the 147 225 individuals with AIDS reported to the Centers for Disease Control from 1 September 1987 to 31 August 1991 were reviewed. The frequency of HIV wasting syndrome and its association with demographic and exposure category variables and with other AIDS-indicator diseases were assessed.Results: A total of 10 525 (7.1%) had wasting syndrome as the only AIDS-indicator condition, and 15726 (10.7%) had wasting syndrome plus at least one other AIDS-indicator condition. Patients with wasting syndrome as the only AIDS diagnosis were more likely to be female, to be black or Hispanic, and to have a mode of HIV exposure reported as injecting drug use, heterosexual contact, or transfusion/hemophilia. The proportion of AIDS patients reported with wasting syndrome varied by geographic distribution, ranging from 11% in the northeastern United States to 47% in Puerto Rico. The association between HIV wasting syndrome and Hispanic ethnicity was due to the much higher prevalence of wasting syndrome reported in Puerto Rican AIDS patients. The other AIDS-indicator conditions most strongly associated with wasting syndrome were isosporiasis, pulmonary candidiasis, esophageal candidiasis, HIV encephalopathy, chronic mucocutaneous herpes simplex, and coccidioidomycosis.Conclusions: The association between HIV wasting syndrome and injecting drug use, and the significant racial/ethnic and geographic differences in prevalence of this AIDS diagnosis may reflect differences in diagnostic and reporting practices and/or access to medical care.