Thyroid autoantibodies: a good marker for the study of symptomless autoimmune thyroiditis.
Thyroid autoantibodies: a good marker for the study of symptomless autoimmune thyroiditis.
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甲状腺自身抗体：研究无症状自身免疫性甲状腺炎的良好标志物。
DOI：
10.1530/acta.0.1140321
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
B. Busnardo
中科院分区：
文献类型：
--
作者：
C. Betterle;G. Callegari;F. Presotto;F. Zanette;B. Pedini;T. Rampazzo;R. Slack;M. Girelli;B. Busnardo
在 3737 名临床上没有甲状腺疾病的受试者中，我们评估了甲状腺微粒体和甲状腺球蛋白抗体的发生率。这些自身抗体存在于 7% 的正常人群、9% 患有各种非自身免疫性疾病的患者以及 11-16% 患有自身免疫性疾病或有患自身免疫性疾病风险的群体中：IDDM、白癜风、斑秃、特发性甲状旁腺功能减退症、阿狄森氏病以及 IDDM 患者的一级亲属。通过 TRH 测试对 197 名血清阳性受试者和 144 名血清阴性对照进行甲状腺功能评估。四分之一 (26%) 的甲状腺自身抗体受试者在 TRH 检测中表现出功能异常，而 144 名血清阴性对照中只有 2.8% 表现出亚临床甲状腺功能减退症。经过 12-44 个月的观察期后，对 102 名持续血清阳性受试者进行了重新评估，其中 31% 显示 TRH 测试反应受损。
In 3737 subjects without clinically thyroid disorders we evaluated the incidence of thyroid microsomal and thyroglobulin antibodies. These autoantibodies were found in 7% of a normal population, in 9% of patients with various non-autoimmune diseases, and in 11-16% of groups who either had or were at risk for autoimmune diseases: patients with IDDM, vitiligo, alopecia areata, idiopathic hypoparathyroidism, Addison's disease, and first-degree relatives of IDDM patients. Functional thyroid evaluation with TRH test was performed in 197 seropositive subjects and 144 seronegative controls. One-quarter (26%) of the subjects with thyroid autoantibodies showed functional abnormalities on TRH testing, whereas only 2.8% of the 144 seronegative controls showed subclinical hypothyroidism. After an observation period of 12-44 months, 102 persistently seropositive subjects were reassessed and 31% of them showed an impairment in TRH test response.