Downregulation of ARID4A and ARID4B promote tumor progression and directly regulated by microRNA-30d in patient with prostate cancer
Downregulation of ARID4A and ARID4B promote tumor progression and directly regulated by microRNA-30d in patient with prostate cancer
复制标题
ARID4A 和 ARID4B 的下调可促进前列腺癌患者的肿瘤进展，并受 microRNA-30d 直接调节。
DOI：
10.1002/jcb.26913
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发表时间：
2018-09-01
影响因子：
4
通讯作者：
Zhong, Wei-De
中科院分区：
文献类型：
--
作者：
Liang, Ying-Ke;Han, Zhao-Dong;Zhong, Wei-De
富AT相互作用结构域4A（ARID 4A）和富AT相互作用结构域4 B（ARID 4 B）属于富AT相互作用结构域（ARID）家族，已被报道是多种人类恶性肿瘤的癌基因或抑癌基因，但其在前列腺癌（PCa）中的功能尚未见报道。本课题组前期研究发现microRNA-30 d（miR-30 d）的表达可预测PCa的不良临床预后，但其作用机制尚未完全阐明。本研究旨在探讨miR-30 d与ARID 4A、ARID 4 B在PCa中表达的相关性，以及ARID 4A、AIRD 4 B在PCa中的临床意义和生物学功能。在本研究中，ARID 4A和ARID 4 B都被确定为miR-30 d的靶基因。PCa组织中miR-30 d mRNA表达与ARID 4A（Pearson相关系数=-0.313，P =0.001）和ARID 4 B（Pearson相关系数=-0.349，P = 0.001）呈显著负相关。
AT-rich interaction domain 4A (ARID4A) and AT-rich interaction domain 4B (ARID4B), which are both the AT-rich interaction domain (ARID) family, have been reported to be oncogene or tumor suppressor gene in various human malignances, but there is no involvement about their functions in prostate cancer (PCa). Our previous study has reported that microRNA-30d (miR-30d) expression can predicted poor clinical prognosis in PCa, however, the underlying mechanisms of miR-30d have not been fully described. The aim of our study is to investigate the expression relevance between miR-30d and ARID4A or ARID4B, and examine the clinical significance and biological function of ARID4A and AIRD4B in PCa. In this study, both ARID4A and ARID4B were identified as the target genes of miR-30d. In addition, the mRNA expression of miR-30d in PCa tissues were significantly negative correlated with ARID4A (Pearson correlation coefficient=-0.313, P=0.001) and ARID4B (Pearson correlation coefficient=-0.349, P