Organocatalytic direct asymmetric aldol reactions in water
Organocatalytic direct asymmetric aldol reactions in water
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DOI：
10.1021/ja0573312
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发表时间：
2006-01-25
影响因子：
15
通讯作者：
Barbas, CF
中科院分区：
文献类型：
--
作者：
Mase, N;Nakai, Y;Barbas, CF
我们已经开发了直接的不对称交叉羟醛缩合反应，可以在水中进行，而无需添加有机溶剂。具有长疏水烷基链的双功能催化剂有效地催化反应，并以优异的产率提供所需的羟醛产物，具有高对映体过量，即使当仅使用等摩尔比的供体和受体时。这些结果揭示了一个有效的设计策略，为发展水性有机催化体系。
We have developed direct asymmetric cross-aldol reactions that can be performed in water without addition of organic solvents. A bifunctional catalyst with a long hydrophobic alkyl chain efficiently catalyzed the reactions and afforded the desired aldol products in excellent yield with high enantiomeric excess, even when only an equal molar ratio of the donor and acceptor was used. These results reveal an effective design strategy for the development of aqueous organocatalytic systems.