Autonomic tone variations before the onset of paroxysmal atrial fibrillation
Autonomic tone variations before the onset of paroxysmal atrial fibrillation
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DOI：
10.1161/01.cir.0000018443.44005.d8
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发表时间：
2002-06-11
期刊：
影响因子：
37.8
通讯作者：
Zimmermann, M
中科院分区：
文献类型：
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作者：
Bettoni, M;Zimmermann, M
背景-导致阵发性心房颤动（PAF）发生的机制非常复杂且不明确。本研究旨在分析一大群患者 PAF 发作前自主神经张力的动态变化。方法和结果 - 对 77 名未经选择的连续 PAF 患者（63 名男性和 14 名女性，年龄 58 +/- 12 岁）的动态心电图进行了分析。总共记录了 147 次持续性房颤（>30 分钟），并进行时域和频域心率变异性分析；使用重复测量方差分析研究了 6 个周期：24 小时周期、PAF 前一小时和 PAF 前 20 分钟分为四个 5 分钟周期。在时域分析中，平均 RR 间隔从 925 +/- 16 线性下降到 906 +/- 16 ms（P
Background-Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients.Methods and Results-Holter tapes from 77 unselected consecutive patients (63 men and 14 women aged 58 +/- 12 years) with PAF were analyzed. A total of 147 episodes of sustained AF (>30 minutes) were recorded and submitted to time-domain and frequency-domain heart rate variability analyses; 6 periods were studied using repeated measures ANOVA: the 24-hour period, the hour preceding PAF, and the 20 minutes before PAF divided into four 5-minute periods, In the time-domain analyses, a linear decrease in mean RR interval from 925 +/- 16 to 906 +/- 16 ms (P