Chlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine.
Chlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine.
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DOI：
10.1007/s40588-016-0028-4
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发表时间：
2016
影响因子：
5.2
通讯作者：
Schoborg RV
中科院分区：
文献类型：
--
作者：
Borel N;Leonard C;Slade J;Schoborg RV
衣原体科是人类和动物的广泛病原体。沙眼衣原体感染可引起人类致盲性沙眼和生殖并发症。肺炎衣原体引起人类呼吸道感染和非典型肺炎。猪衣原体感染与猪的结膜炎、腹泻和体重增加失败有关。人类和家养动物的衣原体感染通常通过抗生素治疗来控制，特别是大环内酯类（通常是阿奇霉素）和四环素类（四环素和强力霉素）。含四环素的饲料也被用于限制感染和促进牲畜种群的增长，尽管由于对抗菌素耐药性发展的日益关注，其使用已经减少。由于Sandoz和Rockey在2010年发表了一篇关于衣原体抗微生物耐药性的优雅综述，我们将综述以下内容：（i）衣原体的抗生素耐药性。suis，（ii）人类衣原体感染获得性耐药性的最新证据，以及（iii）可能导致治疗失败的抗生素耐药性的最新非遗传机制。
The Chlamydiaceae are widespread pathogens of both humans and animals. Chlamydia trachomatis infection causes blinding trachoma and reproductive complications in humans. Chlamydia pneumoniae causes human respiratory tract infections and atypical pneumonia. Chlamydia suis infection is associated with conjunctivitis, diarrhea, and failure to gain weight in domestic swine. Chlamydial infections in humans and domesticated animals are generally controlled by antibiotic treatment—particularly macrolides (usually azithromycin) and tetracyclines (tetracycline and doxycycline). Tetracycline-containing feed has also been used to limit infections and promote growth in livestock populations, although its use has decreased because of growing concerns about antimicrobial resistance development. Because Sandoz and Rockey published an elegant review of chlamydial anti-microbial resistance in 2010, we will review the following: (i) antibiotic resistance in C. suis, (ii) recent evidence for acquired resistance in human chlamydial infections, and (iii) recent non-genetic mechanisms of antibiotic resistance that may contribute to treatment failure.