Understanding Caries From the Oral Microbiome Perspective.
Understanding Caries From the Oral Microbiome Perspective.
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DOI：
10.1080/19424396.2016.12221036
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
A. Tanner;C. Kressirer;L. Faller
中科院分区：
文献类型：
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作者：
A. Tanner;C. Kressirer;L. Faller
龋病是口腔的一种重要疾病，具有重要的临床意义。龋齿是由于健康的口腔微生物组转变为微生物多样性减少的产酸群落，以响应过量的膳食糖摄入。微生物培养、分子鉴定、基因表达和代谢组学分析显示了整个微生物群落在理解微生物组在龋齿病理学中的作用方面的重要性。
Dental caries is a major disease of the oral cavity with profound clinical significance. Caries results from a transition of a healthy oral microbiome into an acidogenic community of decreased microbial diversity in response to excessive dietary sugar intake. Microbiological cultivation, molecular identification, gene expression and metabolomic analyses show the importance of the entire microbial community in understanding the role of the microbiome in the pathology of caries.