The relationship between ventricular size at 1 month and outcome at 2 years in infants less than 30 weeks' gestation
The relationship between ventricular size at 1 month and outcome at 2 years in infants less than 30 weeks' gestation
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DOI：
10.1136/archdischild-2013-304374
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发表时间：
2014-05-01
影响因子：
4.4
通讯作者：
Cheong, Jeanie L. Y.
中科院分区：
文献类型：
--
作者：
Fox, Lisa M.;Choo, Pauline;Cheong, Jeanie L. Y.
颅超声脑生物测量已用于早产儿，特别是脑室扩大的情况下。虽然已经发现使用MRI的脑生物计量测量与长期结果相关，目的评价极早产儿1月龄时使用颅超声测量的脑室大小与2岁时神经发育结果之间的关系。方法采用25 ~ 35天的数字颅超声图像，由两名观察者独立分析了44名妊娠期小于30周的婴儿的年龄。排除了具有显著超声异常的婴儿。一系列的超声线性措施与贝利婴幼儿发展量表，第三版（Bayley-III）的运动，语言和认知综合评分在2年使用线性regression.Results较大的侧脑室大小（前角宽度，脑室高度，中脑室高度）和较大的脑室脑双顶比相关较差的运动综合评分在2年。在运动结果方面，脑室-脑比小于0.3令人放心。2年时的语言综合评分与较大的中体心室高度相关。几乎没有证据表明与认知综合scores.Conclusions在一个月的年龄在顶叶区域较大的侧脑室相关的运动发育较差，在2年。较大的心室测量值也与早期语言发育较慢有关。在极早产儿中，颅超声生物特征测量作为后期结局的生物标志物的作用值得进一步研究。
Background Cranial ultrasound cerebral biometric measurements have been used in preterm neonates, particularly in cases of ventriculomegaly. While cerebral biometric measures using MRI have been found to correlate with long-term outcome, the relationship between cranial ultrasound biometric measures and neurodevelopmental outcome has not been established.Objective To assess the relationship between ventricular size at 1 month of age using cranial ultrasound and neurodevelopmental outcome at 2 years in very preterm infants.Method Digital cranial ultrasound images taken between 25 and 35 days of age of 44 infants born at less than 30 weeks' gestation were analysed independently by two observers. Infants with significant ultrasound abnormalities were excluded. A range of ultrasound linear measures were correlated with Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) motor, language and cognitive composite scores at 2 years using linear regression.Results Larger lateral ventricular sizes (anterior horn width, ventricular height, midbody ventricular height) and larger ventricular-brain biparietal ratios were related to poorer motor composite score at 2 years. A ventricular-brain ratio of less than 0.3 was reassuring with regard to motor outcome. Poorer language composite scores at 2 years were associated with larger midbody ventricular heights. There was little evidence of a relationship with the cognitive composite score.Conclusions Larger lateral ventricles in the parietal region at a month of age were related to poorer motor development at 2 years. Larger ventricular measurements were also related to slower early language development. The role of cranial ultrasound biometric measures as biomarkers of later outcome in very preterm infants warrants further investigation.