Guilu Erxian Glue (龟鹿二仙胶) Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16INK4a-Rb Signaling Pathway
Guilu Erxian Glue (龟鹿二仙胶) Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16INK4a-Rb Signaling Pathway
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DOI：
10.1007/s11655-020-3098-3
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发表时间：
2020-09
影响因子：
2.9
通讯作者：
Jue Wang;Yinyin Ying;Zhao-hui Chen;Ke-ding Shao;Wei-ping Zhang;Sheng-you Lin
中科院分区：
文献类型：
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作者：
Jue Wang;Yinyin Ying;Zhao-hui Chen;Ke-ding Shao;Wei-ping Zhang;Sheng-you Lin
目的观察龟鹿二仙胶对环磷酰胺诱导的小鼠骨髓造血干细胞衰老的影响，并探讨其作用机制。结果与模型组比较，银杏叶提取物可明显提高细胞活力和增殖能力（P< 0.05或P< 0.01），降低β-gal表达。结论：银杏叶提取物可减轻环磷酰胺诱导的小鼠肝星状细胞衰老，且p16蛋白表达减少。
OBJECTIVE@# To evaluate the effect of Guilu Erxian Glue (, GEG) on cyclophosphamide (CTX)-induced bone marrow hematopoietic stem cells (HSCs) senescence in mice and explore the underlying mechanism.@* METHODS@# The H@* RESULTS@# Compared with the model group, GEG increased cell viability as well as proliferation (P< 0.05 or P< 0.01) and reduced β-gal expression. Furthermore, GEG significantly decreased the expressions of p16@* CONCLUSION@# GEG can alleviate CTX-induced HSCs senescence in mice, and the p16