A review of antioxidants and Alzheimer's disease.
A review of antioxidants and Alzheimer's disease.
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DOI：
10.1080/10401230500296428
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发表时间：
2005-10-01
期刊：
影响因子：
--
通讯作者：
Gupta, Sanjay
中科院分区：
文献类型：
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作者：
Frank, Bradford;Gupta, Sanjay
背景技术背景：在这篇文章中，我们回顾了各种各样的研究，并得出结论的有用性，或缺乏的，具体的抗氧化剂在预防阿尔茨海默氏病（AD）。方法：国家医学图书馆的数据库进行了搜索，1996年至2004年使用的搜索词“阿尔茨海默氏症，抗氧化剂，抗氧化剂。结果：确定了300多篇文章，并根据与主题的相关性选择了187篇文章。在帮助预防AD方面显示出希望的药物包括：1）陈年大蒜提取物，2）姜黄素，3）褪黑激素，4）白藜芦醇，5）银杏叶提取物，6）绿色茶，7）维生素C和8）维生素E。结论：虽然抗氧化剂预防AD的临床价值通常是模糊的，但可以根据以下因素推荐一些抗氧化剂：1）流行病学证据，2）已知的预防其他疾病的益处，以及3）该物质的良性性质。建议进行长期前瞻性研究。
BACKGROUND: In this article, we review a diverse body of research and draw conclusions about the usefulness, or lack there-of, of specific antioxidants in the prevention of Alzheimer's disease (AD).METHODS: The National Library of Medicine's database was searched for the years 1996-2004 using the search terms "Alzheimer's, anti-oxidants, antioxidants."RESULTS: Over 300 articles were identified and 187 articles were selected for inclusion based on relevance to the topic. Agents that show promise in helping prevent AD include: 1) aged garlic extract, 2) curcumin, 3) melatonin, 4) resveratrol, 5) Ginkgo biloba extract, 6) green tea, 7) vitamin C and 8) vitamin E.CONCLUSIONS: While the clinical value of antioxidants for the prevention of AD is often ambiguous, some can be recommended based upon: 1) epidemiological evidence, 2) known benefits for prevention of other maladies, and 3) benign nature of the substance. Long-term, prospective studies are recommended.