Between-Subject Variability in Healthy Eyes as a Primary Source of Structural-Functional Discordance in Patients With Glaucoma.
Between-Subject Variability in Healthy Eyes as a Primary Source of Structural-Functional Discordance in Patients With Glaucoma.
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DOI：
10.1167/iovs.15-18633
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发表时间：
2016-02
影响因子：
4.4
通讯作者：
Swanson WH
中科院分区：
文献类型：
--
作者：
Ashimatey BS;Swanson WH
用独立数据集检验健康眼受试者间变异性是青光眼患者结构-功能不一致的主要来源这一发现。对55名对照受试者的一只眼睛和英国青光眼治疗研究中的245名患者的右眼的神经视网膜边缘面积、视网膜神经纤维层厚度和周边测量数据进行分析。使用海德堡视网膜断层扫描仪（HRT）、Stratus光学相干断层扫描仪（OCT）和Humphrey场分析仪（HFA）收集数据。不一致性被量化为Bland-Altman缺陷深度分析的一致性限度的宽度。计算患者组和对照组的方差比（F检验），以比较HFA-OCT、HFA-HRT和OCT-HRT。Bonferroni校正要求P小于0.017才有统计学显著性。患者的不一致性也被量化为使用Hood-Kardon模型从对照组的不一致性计算的95%预测区间，用于HFA-OCT比较。HFA-OCT、HFA-HRT和OCT-HRT比较患者和对照组不一致性的F比分别为0.77、1.43和1.32，P值分别为0.88、0.06和0.11。对于Hood-Kardon模型，4.7%的患者的不一致性超出了根据对照组不一致性计算的95%预测区间。当对患者左眼重复所有比较时，获得了相似的结果。这些结果证实了以前的研究结果，即健康眼睛的受试者之间的变异性是青光眼患者结构-功能不一致的主要来源，并将这一发现扩展到结构-结构比较。
To test with an independent data set the finding that between-subject variability in healthy eyes is the primary source of structural–functional discordance in patients with glaucoma. Neuroretinal rim area, retinal nerve fiber layer thickness, and perimetric data were analyzed for one eye in each of 55 control subjects and for 245 right eyes of patients in the United Kingdom Glaucoma Treatment Study. Data were gathered with the Heidelberg Retina Tomograph (HRT), Stratus Optical Coherence Tomograph (OCT), and Humphrey Field Analyzer (HFA). Discordance was quantified as width of the limits of agreement from a Bland-Altman analysis of depth of defect. The ratio of variances (F test) for the patient and control groups was computed for comparisons of HFA-OCT, HFA-HRT, and OCT-HRT. Bonferroni adjustment required P less than 0.017 for statistical significance. The discordance in the patients was also quantified as the 95% prediction interval computed from the discordance in controls using the Hood-Kardon model for the HFA-OCT comparison. The F ratio comparing discordance in patients and controls was 0.77, 1.43, and 1.32 for the HFA-OCT, HFA-HRT, and OCT-HRT comparisons with P values 0.88, 0.06, and 0.11, respectively. For the Hood-Kardon model, 4.7% of the patients had discordance outside the 95% prediction interval computed from the discordance in controls. Similar results were obtained when all comparisons were repeated for left eyes of patients. These results confirm previous findings that between-subject variability in healthy eyes is the primary source of structural–functional discordance in patients with glaucoma, and extends this finding to a structural–structural comparison.