P16 and p53 play distinct roles in different subtypes of breast cancer.
P16 and p53 play distinct roles in different subtypes of breast cancer.
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P16 和 P53 在不同亚型乳腺癌中发挥不同作用
DOI：
10.1371/journal.pone.0076408
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Pang D
中科院分区：
文献类型：
--
作者：
Shan M;Zhang X;Liu X;Qin Y;Liu T;Liu Y;Wang J;Zhong Z;Zhang Y;Geng J;Pang D
乳腺癌是一种异质且复杂的疾病，乳腺癌的亚型可能涉及独特的分子机制。 p16INK4a 和 p53 途径是参与细胞周期控制的两条主要途径。它们还在肿瘤发生中发挥关键作用。然而，这些途径的作用在乳腺癌亚型中是否不同尚不清楚。因此，我们研究了不同乳腺癌亚型中的 p16 和 p53 表达，以确定它们对这些癌症的贡献。共比较400例非浸润性导管原位癌（DCIS）和浸润性导管癌（IDC），包括主要分子亚型Luminal-A、Luminal-B、Her-2和三阴性亚型，与50例正常对照进行比较。 DCIS各亚型中Luminal-A癌中p16表达水平最低，而IDC的Luminal-A癌中p16表达水平上调（P<0.008）。三阴性乳腺癌的特点是 p53 过表达与高水平 p16 表达相关。研究发现，导管原位癌 (DCIS) 中 p16 高表达的管腔病变类型更有可能发展为侵袭性乳腺癌，这可能是由于 p53 功能障碍所致。综上所述，本研究表明，luminal-A 乳腺癌中 p16 的表达与其从 DCIS 到 IDC 的进展相关，并且 p53 和 p16 表达对于 DCIS 和 IDC 中三阴性乳腺癌的发展都很重要。
Breast cancers are heterogeneous and complex diseases, and subtypes of breast cancers may involve unique molecular mechanisms. The p16INK4a and p53 pathways are two of the major pathways involved in control of the cell cycle. They also play key roles in tumorigenesis. However, whether the roles of these pathways differ in the subtypes of breast cancer is unclear. Therefore, p16 and p53 expression were investigated in different breast cancer subtypes to ascertain their contributions to these cancers. A total of 400 cases of non-invasive ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC), including the major molecular subtypes luminal-A, luminal-B, Her-2, and triple-negative subtypes, and 50 cases of normal controls were compared. Luminal-A cancers expressed the lowest level of p16 among the subtypes in DCIS, and the level of p16 expression was up-regulated in the luminal-A of IDC (P<0.008). Triple-negative breast cancers were characterized by a correlation of p53 overexpression with a high level of p16 expression. Luminal lesion types with high p16 expression in DCIS were found to be more likely to develop into aggressive breast cancers, possibly promoted by p53 dysfunction. Taken together, the present study suggest that p16 expression in luminal-A breast cancers is associated with their progression from DCIS to IDC, and both p53 and p16 expressions are important for the development of triple-negative breast cancers in DCIS and IDC.
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影响因子：
50.3
作者：
Crawford, YG;Gauthier, ML;Tlsty, TD
通讯作者：
Tlsty, TD
影响因子：
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Olivier, M;Langerod, A;Borresen-Dale, AL
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影响因子：
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作者：
Geradts, J;Ingram, CD
通讯作者：
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