Otolith deprivation induces optokinetic compensation
Otolith deprivation induces optokinetic compensation
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DOI：
10.1152/jn.00147.2005
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发表时间：
2005-11-01
影响因子：
2.5
通讯作者：
De Jeu, MTG
中科院分区：
文献类型：
--
作者：
Andreescu, CE;De Ruiter, MM;De Jeu, MTG
根据多感觉整合理论，前庭、视动和本体感觉输入协同作用以维持视觉世界的稳定视网膜图像。然而，耳石器官在多大程度上参与了这一过程，以及耳石输入的特定损失是否得到了补偿，这仍然是一个谜。在这里，我们研究了补偿性眼球运动倾斜小鼠，缺乏耳石症，因为在otopetrin 1突变。倾斜的小鼠在静态滚动范例中表现出非常小的眼睛在眼眶中的位移，这表明没有功能性耳石器官。与头部相对于重力的位置无关，倾斜小鼠的角前庭眼反射的增益和相位超前分别减少和增加（频率为0.2至1 Hz，峰值加速度为8至197度/s（2））。此外，缺乏耳石输入增加前庭系统对刺激频率的依赖性。与此相反，在倾斜的小鼠的视动反射的增益是显着高于在低频率范围内比对照组小鼠，无论小鼠在空间中的位置或平面的眼球运动。为了解释这些结果，使用了一个简单的模型，其中嵌入了多感觉整合单元。通过这个模型，我们能够模拟观察到的所有行为。因此，我们的数据和模型支持的多感觉整合系统的存在，并揭示了一个补偿性增强的视动反射倾斜小鼠，表明在耳石和视觉驱动信号的处理自适应协同作用。
According to the multisensory integration theory vestibular, optokinetic and proprioceptive inputs act in concert to maintain a stable retinal image of the visual world. Yet, it remains elusive to what extent the otolith organs contribute to this process and whether a specific loss of otolith input is compensated for. Here we investigated the compensatory eye movements in tilted mice, which lack otoconia because of a mutation in otopetrin 1. Tilted mice showed very small displacements of the eyes in the orbit during static roll paradigms, suggesting the absence of functional otolith organs. Independent of head position with respect to gravity, the gain and phase lead of angular vestibuloocular reflex of tilted mice were decreased and increased, respectively (frequencies 0.2 to 1 Hz and peak accelerations 8 to 197 degrees/s(2), respectively). Furthermore, lack of otolith input increases the dependency of the vestibular system on stimulus frequency. In contrast, the gain of optokinetic reflex in tilted mice was significantly higher in the low-frequency range than in control mice, regardless of the position of the mice in space or the plane of the eye movements. To explain these results, a simple model was used in which a multisensory integration unit was embedded. With this model, we were able to simulate all the behaviors observed. Thus our data and the model support the presence of the multisensory integration system and revealed a compensatory enhanced optokinetic reflex in tilted mice, indicating an adaptive synergism in the processing of otolith and visually driven signals.