In vivo and in vitro patch-clamp recording analysis of the process of sensory transmission in the spinal cord and sensory cortex.
In vivo and in vitro patch-clamp recording analysis of the process of sensory transmission in the spinal cord and sensory cortex.
复制标题
DOI：
10.2114/jpa.24.93
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
M. Yoshimura;A. Doi;M. Mizuno;H. Furue;T. Katafuchi
中科院分区：
文献类型：
--
作者：
M. Yoshimura;A. Doi;M. Mizuno;H. Furue;T. Katafuchi
在脊髓中的感觉输入被整合和修改之后，信息被传输到初级感觉皮质，在那里整合的信息被进一步处理和感知。脊髓中感觉信息的处理已经被深入研究。然而，大脑皮层如何处理这些信息的机制仍不清楚。为了解大鼠背角和皮层感觉加工的相关性，本实验对大鼠背角和感觉皮层进行了在体和体外膜片钳记录。虽然背角神经元显示自发的和由伤害性和非伤害性刺激诱发的EPSCs，但大多数位于皮质表面100~1000微米处的体感神经元表现出振荡活动，并接受非伤害性但非伤害性受体的突触输入。这些观察表明，皮质神经元的突触反应是以更复杂的方式进行的；这可能是由于丘脑和皮质之间的相互突触联系所致。
Following the integration and modification of the sensory inputs in the spinal cord, the information is transmitted to the primary sensory cortex where the integrated information is further processed and perceived. Processing of the sensory information in the spinal cord has been intensively investigated. However, the mechanisms of how the inputs are processed in the cortex are still unclear. To know the correlation of the sensory processing in the dorsal horn and cortex, in vivo and in vitro patch-clamp recordings were made from rat dorsal horn and sensory cortex. Although dorsal horn neurons showed spontaneous and evoked EPSCs by noxious and non-noxious stimuli, most somatosensory neurons located at 100 to 1000 microm from the surface of the cortex exhibited an oscillatory activity and received synaptic inputs from non-noxious but not noxious receptors. These observations suggest that the synaptic responses in cortical neurons are processed in a more complex manner; and this may be due to the reciprocal synaptic connection between thalamus and cortex.