Emerging roles of angiopoietin‐like proteins in inflammation: Mechanisms and potential as pharmacological targets
Emerging roles of angiopoietin‐like proteins in inflammation: Mechanisms and potential as pharmacological targets
复制标题
血管生成素样蛋白在炎症中的新作用：机制和作为药理学靶点的潜力
DOI：
10.1002/jcp.30534
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发表时间：
2021-07
影响因子：
5.6
通讯作者：
Kun Huang
中科院分区：
文献类型：
--
作者：
Jing Yang;Qiu-Yi Song;Shu-Xuan Niu;Huijing Chen;Robert Petersen;Yu Zhang;Kun Huang
血管生成素样蛋白（ANGPTLs），一个由八种分泌糖蛋白组成的家族，称为ANGTPL 1 -8，参与血管生成、脂质代谢、癌症进展和炎症。它们在调节脂质代谢中的作用已被深入研究，因为一些ANGPTL是高脂血症和相关心血管疾病的有希望的药理学靶点。近年来，ANGPTLs在炎症反应中的作用引起了人们的广泛关注。首先，炎性疾病中多种循环ANGPTL水平升高使其成为潜在的疾病生物标志物。其次，多种ANGPTL通过各种机制调节急性或慢性炎症，包括通过其作为整联蛋白的配体的作用触发炎症信号传导或形成同源/异源寡聚体以通过细胞外或细胞内机制调节信号转导。由于炎症反应的失调是许多疾病中的关键触发因素，因此了解ANGPTL在炎症中的作用将有助于药物/疗法的开发。本文就ANGPTLs在炎症及炎性疾病中的作用、机制及潜在的治疗价值作一综述。
Angiopoietin-like proteins (ANGPTLs), a family of eight secreted glycoproteins termed ANGTPL1-8, are involved in angiogenesis, lipid metabolism, cancer progression, and inflammation. Their roles in regulating lipid metabolism have been intensively studied, as some ANGPTLs are promising pharmacological targets for hypertriglyceridemia and associated cardiovascular disease. Recently, the emerging roles of ANGPTLs in inflammation have attracted great attention. First, elevated levels of multiple circulating ANGPTLs in inflammatory diseases make them potential disease biomarkers. Second, multiple ANGPTLs regulate acute or chronic inflammation via various mechanisms, including triggering inflammatory signaling through their action as ligands for integrin or forming homo- /hetero-oligomers to regulate signal transduction via extra- or intracellular mechanisms. As dysregulation of the inflammatory response is a critical trigger in many diseases, understanding the roles of ANGPTLs in inflammation will aid in drug/therapy development. Here, we summarize the roles, mechanisms, and potential therapeutic values for ANGPTLs in inflammation and inflammatory diseases.
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