Association of TLR polymorphisms with development of tuberculosis in Indonesian females
Association of TLR polymorphisms with development of tuberculosis in Indonesian females
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DOI：
10.1111/j.1399-0039.2011.01821.x
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发表时间：
2012-03-01
期刊：
影响因子：
--
通讯作者：
Tokunaga, K.
中科院分区：
文献类型：
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作者：
Kobayashi, K.;Yuliwulandari, R.;Tokunaga, K.
结核病（TB）是由结核分枝杆菌（Mycobacterium tuberculosis）引起的，并且是全世界发病率和死亡率的主要原因。已经研究了许多候选基因与TB的可能关联。Toll样受体（TLR）在人类先天免疫系统中发挥重要作用。TLR的多态性和功能已被研究，以确定与特定的传染病，包括结核病的关联。在这里，我们研究了TLR和TLR信号传导基因的单核苷酸多态性（SNP）是否与印度尼西亚和越南人群的结核病易感性相关。使用基因型（P = 2.76E-04）和隐性（AA vs AG+GG，P = 2.48E-04，比值比= 1.827，95%置信区间= 1.321-2.526）模型，在分类的印度尼西亚女性组中观察到结核病易感性与位于TLR 9内含子的SNP rs352139之间存在统计学显著关联。对印度尼西亚和越南人群的荟萃分析显示，rs352139在隐性模型中与结核病显著相关。提示TLR 9基因多态性可能与结核分枝杆菌的易感性有关。亚洲人的肺结核
Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is a major cause of morbidity and mortality worldwide. Many candidate genes have been investigated for a possible association with TB. Toll-like receptors (TLRs) are known to play important roles in human innate immune systems. Polymorphisms in and functions of TLRs have been investigated to identify associations with specific infectious diseases, including TB. Here, we examined whether single-nucleotide polymorphisms (SNPs) in TLRs and genes in TLR signaling were associated with TB susceptibility in Indonesian and Vietnamese populations. A statistically significant association was observed between TB susceptibility in a classified Indonesian female group and rs352139, an SNP located in the intron of TLR9, using the genotype (P = 2.76E-04) and recessive (AA vs AG+GG, P = 2.48E-04, odds ratio = 1.827, 95% confidence interval = 1.321-2.526) models. Meta-analysis of the Indonesian and Vietnamese populations showed that rs352139 was significantly associated with TB in the recessive model. This finding indicated that a TLR9 polymorphism might have an important role in the susceptibility to M. tuberculosis in Asian populations.