Enhancement of ultrasound contrast agent in high-intensity focused ultrasound ablation
Enhancement of ultrasound contrast agent in high-intensity focused ultrasound ablation
复制标题
超声造影剂在高强度聚焦超声消融中的增强作用
DOI：
10.1007/bf02850207
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发表时间：
2006-11-01
影响因子：
3.8
通讯作者：
He, Guangbin
中科院分区：
文献类型：
--
作者：
Luo, Wen;Zhou, Xiaodong;He, Guangbin
高强度聚焦超声（HIFU）正在成为一种越来越有吸引力的消融方式。 HIFU 的增强是全世界范围内讨论和研究的一个重要问题。超声造影剂被认为是改变声学特性和改善焦点区域能量沉积的有效介质。已经研究了微泡在 HIFU 消融中诱导增强加热、空化和其他相关事件中的作用，目的是改善凝固坏死体积或降低声功率和暴露时间。因此，随着超声造影剂的使用，HIFU 的应用有望变得更加高效、安全和准确，并产生更少的副作用。本文回顾了通过体外和体内实验研究超声造影剂在 HIFU 消融中的增强作用的研究；提供了对该增强机制的结果的分析。
High-intensity focused ultrasound (HIFU) is becoming an increasingly attractive modality for ablation. Enhancement of HIFU is an important issue that has been discussed and investigated worldwide. Ultrasound contrast agents are considered to constitute an efficient medium for changing acoustic characteristics and improving energy deposition in the focal region. The role of microbubbles in inducing enhanced heating, cavitation, and other related events in HIFU ablation has been investigated, with the goal of improving coagulation necrosis volume or decreasing acoustic power and exposure duration. Consequently, with the use of ultrasound contrast agents, applications of HIFU are expected to become more efficient, safe, and accurate and to produce fewer adverse effects. This paper reviews studies that have been conducted to investigate the enhancement of ultrasound contrast agents in HIFU ablation through experiments that were carried out in vitro and in vivo; an analysis of results of this enhancement mechanism is provided.