DETERMINATION OF PRIMARY MOTONEURON IDENTITY IN DEVELOPING ZEBRAFISH EMBRYOS
DETERMINATION OF PRIMARY MOTONEURON IDENTITY IN DEVELOPING ZEBRAFISH EMBRYOS
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DOI：
10.1126/science.1708527
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发表时间：
1991-04-26
期刊：
影响因子：
56.9
通讯作者：
EISEN, JS
中科院分区：
文献类型：
--
作者：
EISEN, JS
通过将已鉴定的斑马鱼胚胎运动神经元移植到新的脊髓位置，研究初级运动神经元的发育决定。 有些细胞从新的位置移回原来的位置，因此很难评价它们是否被确定。 在保持在其新位置的细胞中，在轴突发生前约1小时移植的细胞形成了适合于其原始索马位置的轴突轨迹，而在轴突发生前2至3小时移植的细胞形成了适合于其新索马位置的形态。 这些结果表明，运动神经元的身份确定轴突发生之前。
The developmental determination of primary motoneurons was investigated by transplanting identified motoneurons in embryonic zebrafish to new spinal cord positions. Some cells moved from the new positions in which they were placed back to their original positions, thus it was difficult to evaluate whether they were determined. Among cells that remained in their new positions, those transplanted about 1 hour before axogenesis developed axonal trajectories that were appropriate for their original soma positions, whereas those transplanted 2 to 3 hours before axogenesis developed morphologies appropriate for their new soma positions. These results suggest that motoneuronal identity is determined before axogenesis.