AN OUTBREAK OF LEPTOSPIROSIS AMONG US ARMY TROOPS IN CANAL ZONE .I. CLINICAL AND EPIDEMIOLOGICAL OBSERVATIONS
AN OUTBREAK OF LEPTOSPIROSIS AMONG US ARMY TROOPS IN CANAL ZONE .I. CLINICAL AND EPIDEMIOLOGICAL OBSERVATIONS
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DOI：
10.4269/ajtmh.1966.15.57
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发表时间：
1966-01-01
影响因子：
3.3
通讯作者：
BEYE, HK
中科院分区：
文献类型：
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作者：
MACKENZIE, RB;REILEY, CG;BEYE, HK
良性钩端螺旋体病的爆发影响了参加运河区夜间丛林演习的 365 名步兵中的 9 人。钩端螺旋体病原学涉及多种血清型。该疾病的特点是“马鞍背”发热曲线、严重的头部和身体疼痛、骨骼压痛以及白细胞计数低至正常。有流行病学证据表明，感染是由于涉水丛林河流的一段而引起的。疫情爆发一个月后，从河流和河岸滞留的 4 种哺乳动物（刺鼠、半棘原鼠、刺袋鼠、Liomys adspersus、负鼠、Didelphis marsupialis、Philander opossum、蝙蝠、Carollia perspicil-lata Micronycteris megalotis、Glosssophaga soricina）中分离出钩端螺旋体。对 167 名非住院士兵进行了血清学调查。 7 人被发现有凝集素，但 7 人中只有 1 人在疫情爆发时出现症状；其他 6 种病毒的滴度与此次疫情无关。通过对钩端螺旋体抗体进行属特异性同源溶解测试，另外 55 名士兵也出现了反应。这些反应不仅仅与巴拿马发生的感染有关。
An outbreak of benign leptospirosis affected 9 of 365 infantry troops who took part in overnight jungle exercises in the Canal Zone. Multiple serotypes were involved in the leptospiral etiology. The illness was characterized by a "saddle-back" fever curve, severe head and body pain, bone tenderness and low to normal leukocyte counts. There was epidemiological evidence that infection had been incurred by wading in a segment of a jungle river. A month after the outbreak, leptospiras were isolated from the river and from 4 species of mammals (spiny rats, Proechimys semispinosus, spiny pocket mice, Liomys adspersus, opossums, Didelphis marsupialis, Philander opossum, bats,Carollia perspicil-lata Micronycteris megalotis, Glossophaga soricina) trapped along its banks. A serological survey was made of 167 non-hospitalized soldiers. Seven were found to have agglutinins but only 1 of the 7 had had symptoms at the time of the outbreak; titers in the other 6 could not be related to the outbreak. Employing a genus-specific homo-lytic test for leptospiral antibodies, reactions were elicited in 55 additional soldiers. These reactions could not be related exclusively to infections incurred in Panama.