[Satellite systems of the basal ganglia--anatomic position, clinical relevance].
[Satellite systems of the basal ganglia--anatomic position, clinical relevance].
复制标题
[基底神经节的卫星系统——解剖位置、临床相关性]
DOI：
10.1055/s-0034-1366372
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Tittgemeyer
中科院分区：
文献类型：
--
作者：
Pelzer;Hintzen;Timmermann;Tittgemeyer
从解剖学和功能角度来看，基底神经节和其他大脑区域的相互作用比之前假设的更加复杂。因此，经典的基底神经节模型必须扩展到至少四个调节运动执行、联想和边缘激励大脑区域的卫星系统：（i）间接投射系统，（ii）纹状体-黑质-纹状体环路，（iii）“超直接”投射系统以及对丘脑底核的附加投射和（iv）来自小脑的对间接投射系统施加影响的多突触连接。对这些卫星系统的研究对于促进我们对基底神经节回路的理解非常有价值，并且可能会更好地理解很大程度上不透明的症状，例如帕金森病的静止性震颤；对这些解剖途径和功能含义的分析可能有助于解释人类多巴胺能治疗和深部脑刺激引起的副作用的模型方法，从而为运动障碍的新治疗方法提供可能性。
The interaction of basal ganglia and other brain regions is more complex regarding anatomic and functional perspectives than previously assumed. Hence, the classical basal ganglia model has to be extended to at least four satellite systems modulating motor-executive, associative and limbic-motivational brain regions:(i) an indirect projection system,(ii) a striato-nigro-striatal loop,(iii) a" hyperdirect" projection system as well as additional projections to the subthalamic nucleus and (iv) multisynaptic connections from the cerebellum exerting influence on the indirect projection system. The investigation of these satellite systems would be invaluable to foster our understanding of basal ganglia circuitries and may yield a better appreciation of largely opaque symptoms like resting tremor in Parkinson's disease; analysis of these anatomic pathways and functional implications may facilitate explanatory model approaches to side effects due to dopaminergic therapy and deep brain stimulation in humans and thereby offer the possibility for new therapeutic approaches in movement disorders.