CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2:: a potential new link between adaptive and innate immunity
CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2:: a potential new link between adaptive and innate immunity
复制标题
DOI：
10.1182/blood-2002-09-2876
复制
发表时间：
2003-04-15
期刊：
影响因子：
20.3
通讯作者：
Caligiuri, MA
中科院分区：
文献类型：
--
作者：
Fehniger, TA;Cooper, MA;Caligiuri, MA
自然杀伤（NK）细胞是提供关键细胞因子的先天淋巴细胞。用于早期宿主防御病原体。人类NK细胞的一个亚群（CD56（亮））组成性地表达高亲和力的白细胞介素2 （IL-2）受体并产生免疫调节细胞因子。在这里，我们证明CD56（明亮）NK细胞存在于人类淋巴结中，并且内源性T细胞来源的IL-2通过NK高亲和力IL-2受体作用，共同刺激CD56（明亮）NK细胞分泌ifn - γ。因此，适应性免疫调节剂影响先天细胞因子的产生，进而可能影响抗原特异性免疫反应的发展。这些数据显示了先天和适应性人类淋巴细胞之间的动态相互作用，并强调了研究免疫成分之间相互作用以整体理解免疫反应的重要性。(C) 2003年由美国血液病学会出版。
Natural killer (NK) cells are innate lymphocytes that provide cytokines critical. for early host defense against pathogens. One subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, We demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole.. (C) 2003 by The American Society of Hematology.