The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
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DOI：
10.1007/s00134-019-05853-1
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发表时间：
2019-11-29
影响因子：
38.9
通讯作者：
Flaatten, Hans
中科院分区：
文献类型：
--
作者：
Guidet, Bertrand;de Lange, Dylan W.;Flaatten, Hans
目的探讨老年急性病患者的病前状态对预后的影响。一些证据表明，老年综合征需要进行评估，但对ICU入院后30天生存率的相对影响知之甚少。本研究的主要目的是描述虚弱，认知能力下降和日常生活活动的患病率，以及合并症和多种药物的存在，并评估其对30天生存率的影响。方法对来自22个国家的242个ICU进行前瞻性队列研究。纳入了2018年5月至2019年5月期间在ICU急性住院6个月的80岁或以上患者。除了常见患者的特征和疾病严重程度外，我们还收集了特定老年综合征的信息，作为30天生存率、虚弱程度和年龄的潜在预测因素。（临床虚弱量表）CFS > 4定义虚弱患者，认知障碍（老年人认知能力下降的知情者问卷（IQCODE），IQCODE >= 3.5定义认知能力下降，残疾（用Katz指数衡量日常生活活动能力）与ADL
Purpose Premorbid conditions affect prognosis of acutely-ill aged patients. Several lines of evidence suggest geriatric syndromes need to be assessed but little is known on their relative effect on the 30-day survival after ICU admission. The primary aim of this study was to describe the prevalence of frailty, cognition decline and activity of daily life in addition to the presence of comorbidity and polypharmacy and to assess their influence on 30-day survival. Methods Prospective cohort study with 242 ICUs from 22 countries. Patients 80 years or above acutely admitted over a six months period to an ICU between May 2018 and May 2019 were included. In addition to common patients' characteristics and disease severity, we collected information on specific geriatric syndromes as potential predictive factors for 30-day survival, frailty (Clinical Frailty scale) with a CFS > 4 defining frail patients, cognitive impairment (informant questionnaire on cognitive decline in the elderly (IQCODE) with IQCODE >= 3.5 defining cognitive decline, and disability (measured the activity of daily life with the Katz index) with ADL