Hormonal control of gestation in the intact rat.
Hormonal control of gestation in the intact rat.
复制标题
完整大鼠妊娠的激素控制。
DOI：
10.1210/endo-86-4-874
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发表时间：
1970
期刊：
影响因子：
4.8
通讯作者：
N. Moudgal
中科院分区：
文献类型：
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作者：
H. G. Raj;N. Moudgal
在妊娠第12天之前，给予妊娠大鼠特异性和良好表征的羊促黄体生成素（LH）兔抗血清，导致阴道出血，随后胎仔吸收。这种效果的抗血清不能逆转的绵羊催乳素或提取物的第12天大鼠胎盘的管理。在肾包膜下同种移植2个垂体也没有逆转这种作用。而0.25-5 μg雌二醇-17 β则无效，4 mg孕酮可克服抗血清的作用。LH下降2-8小时对胎儿生长也有损害。抗血清的这些作用可被LH同时给药逆转。因此，已有证据表明LH通过刺激类固醇生成维持妊娠至第12天。在尝试的3种促性腺激素（LH、催乳素和FSH）中，在妊娠后半期给予LH导致分娩推迟。类似的结果也得到了与广告…
Administration of specific and wellcharacterized rabbit antisera to ovine luteinizing hormone (LH) to pregnant rats, before day 12 of gestation, resulted in vaginal bleeding followed by resorption of fetuses. This effect of the antiserum could not be reversed by the administration of either ovine prolactin or extracts of day 12 rat placentae. Homotransplantation of 2 pituitaries under the kidney capsule also did not reverse this effect. Whereas 0.25–5 μg estradiol-17β was ineffective, 4 mg of progesterone could overcome the effects of the antiserum. Deprivation of LH even for 2–8 hr was injurious to fetal growth. These effects of the antiserum could be reversed by the simultaneous administration of LH. Thus, evidence has been presented to show that LH maintains pregnancy up to day 12 by stimulating steroidogenesis. Of the 3 gonadotropins (LH, prolactin and FSH) tried, administration of LH during the second half of pregnancy resulted in postponement of parturition. Similar results were obtained with the ad...