Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting
Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting
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DOI：
10.1159/000100954
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发表时间：
2007-01-01
影响因子：
3.9
通讯作者：
Akyildiz, Mahmut
中科院分区：
文献类型：
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作者：
Aksungar, Fehime B.;Topkaya, Aynur E.;Akyildiz, Mahmut
背景：众所周知，营养习惯、睡眠模式和进餐频率对维持人类健康有着深远的影响。斋月是伊斯兰教的一个宗教月，穆斯林在白天不吃不喝。限制食物和饮料摄入的持续时间约为12小时/天，持续1个月，这使得斋月成为长期间歇性禁食的典范。研究方法：为了评价食物摄入的长期改变对炎症标志物和生化参数的影响，40名正常体重的健康志愿者[ 20名年龄在20至38岁之间的女性，20名年龄在23至39岁之间的男性，体重指数（BMI）< 25 kg/m2]和另外28名健康年龄和BMI匹配的志愿者（14名男性，14名女性）参加了这项研究。在斋月前1周、斋月最后一周和斋月后3周采集静脉血样。检测血清白细胞介素-6（IL-6）、C反应蛋白（CRP）、同型半胱氨酸、维生素B-12、叶酸、总胆固醇（TC）、甘油三酯、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）水平。结果：血清总胆固醇、甘油三酯和低密度脂蛋白水平无明显变化。TC/HDL比率（HDL风险因素）在斋月期间和之后在禁食组的两种性别中均有所下降，而在非禁食组中没有变化。在斋月期间，与基础值（斋月前1周）相比，禁食受试者的IL-6（p <0.001）、CRP（p < 0.001）和同型半胱氨酸（p < 0.01）水平显著降低。总结：我们的研究结果表明，在斋月这样的模型中，长时间的间歇性禁食对身体的炎症状态和心血管疾病的危险因素（如同型半胱氨酸、CRP和TC/HDL比值）有一些积极的影响。版权所有（c）2007 S. Karger AG，巴塞尔
Background: It is well known that nutritional habits, sleeping patterns and meal frequency have profound effects on maintaining human health. Ramadan is a religious month for Islam, during which Muslims do not eat and drink during the daylight hours. The duration of restricted food and beverage intake is approximately 12 h/day for 1 month, which makes Ramadan a model of prolonged intermittent fasting. Methods: In order to evaluate the effects of long- lasting modifications of food intake on inflammatory markers and biochemical parameters 40 healthy volunteers of normal weight [ 20 females aged between 20 and 38 years, 20 males aged between 23 and 39 years, body mass index (BMI) < 25 kg/m(2)] who fasted during Ramadan and another 28 healthy age and BMI-matched volunteers (14 males, 14 females) who did not fast participated in the study. Venous blood samples were taken 1 week before Ramadan, during the last week of Ramadan and 3 weeks after Ramadan. Serum interleukin-6 (IL-6), C-reactive protein (CRP), homocysteine, vitamin B-12, folate, total cholesterol (TC), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Results: No significant changes were observed in serum total cholesterol, triglycerides and LDL levels. TC/HDL ratio (HDL risk factor) was decreased during and after Ramadan in both genders in the fasting group while there were no changes in the nonfasting group. IL-6 (p < 0.001), CRP (p < 0.001) and homocysteine (p < 0.01) levels were significantly low during Ramadan in the fasting subjects of both genders when compared to basal values (1 week before Ramadan). Conclusion: Our results demonstrate that prolonged intermittent fasting in a model like Ramadan has some positive effects on the inflammatory status of the body and on the risk factors for cardiovascular diseases such as homocysteine, CRP and TC/HDL ratio. Copyright (c) 2007 S. Karger AG, Basel