Loquat-Inspired Janus Drug Delivery System for Flexible and Robust Tumor Targeting Therapy
Loquat-Inspired Janus Drug Delivery System for Flexible and Robust Tumor Targeting Therapy
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受枇杷启发的 Janus 药物输送系统，用于灵活而稳健的肿瘤靶向治疗
DOI：
10.1021/acsbiomaterials.8b01138
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发表时间：
2019
影响因子：
--
通讯作者：
Wang Xiaolei
中科院分区：
文献类型：
--
作者：
Liu Yu;Wei Chaochao;Huang Long;Liu Weizhu;Lin Jiaqi;Chen Leifeng;Yang Yalan;Hu Ping;Liu Anwen;Wang Xiaolei
受这颗枇杷果实形状的启发，我们在这里开发了一款形状相似的Janus载体。这种特殊的金棒-部分裸露结构不仅显着提高了药物的载药能力，还提高了其红外响应效率。从而实现药物光热治疗的较好效果。借助于外部3D打印药物引导装置，该载体可以准确地到达不同的受影响区域。随后的红外线触发了多个肿瘤治疗，从而可以在指定的位置进行。相应的实验结果表明，所提出的药物输送系统对两种不同的肿瘤靶向治疗具有可靠性、灵活性和生物相容性。
With the inspiration of the shape of the loquat fruit, here, we developed a similarly shaped Janus carrier. This peculiar gold rod-partially exposed structure not only significantly increased the drug loading capability but also improved its infrared response efficiency. A better effect of drug-photothermal treatment thus could be realized. With the aid of an external 3D printed drug guiding device, this carrier could accurately reach different affected areas. The subsequent infrared triggered multiple tumor therapy, thus, could be conducted in the designated location. The corresponding experimental results demonstrated the reliability, flexibility, and biocompatibility of the proposed drug delivery system for two different tumor targeting treatments.