Collagen Mimetic Peptides: Progress Towards Functional Applications.
Collagen Mimetic Peptides: Progress Towards Functional Applications.
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DOI：
10.1039/c1sm05329a
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发表时间：
2011-09-21
期刊：
影响因子：
3.4
通讯作者：
Kim D
中科院分区：
文献类型：
--
作者：
Yu SM;Li Y;Kim D
传统上，胶原模拟肽（CMPs）已被用于阐明胶原三螺旋结构及其稳定的因素。在过去几十年中积累的关于胶原结构和细胞-细胞外基质（ECM）相互作用的丰富基础知识导致了最近的研究爆发，探索cmp的潜力，以重建用于生物医学应用的天然胶原的高阶组装和生物学功能。虽然这类研究的很大一部分仍处于早期阶段，但胶原蛋白三螺旋结构已成为一种很有前途的结构基序，用于工程自组装，类似于天然组织支架的分层结构，有望表现出独特或增强的生物活性。本文综述了近年来在拟胶原肽领域的研究进展，这些研究对潜在生物医学用途的工程类胶原材料具有直接和间接的影响。讨论了各种cmp和胶原样蛋白，它们模仿天然胶原的结构或功能特征，特别强调为对胶原工程感兴趣的生物工程师和生物材料科学家提供有用的信息。
Traditionally, collagen mimetic peptides (CMPs) have been used for elucidating the structure of the collagen triple helix and the factors responsible for its stabilization. The wealth of fundamental knowledge on collagen structure and cell-extracellular matrix (ECM) interactions accumulated over the past decades has led to a recent burst of research exploring the potential of CMPs to recreate the higher order assembly and biological function of natural collagens for biomedical applications. Although a large portion of such research is still at an early stage, the collagen triple helix has become a promising structural motif for engineering self-assembled, hierarchical constructs similar to natural tissue scaffolds which are expected to exhibit unique or enhanced biological activities. This paper reviews recent progress in the field of collagen mimetic peptides that bears both direct and indirect implications to engineering collagen-like materials for potential biomedical use. Various CMPs and collagen-like proteins that mimic either structural or functional characteristics of natural collagens are discussed with particular emphasis on providing helpful information to bioengineers and biomaterials scientists interested in collagen engineering.