Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease
Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease
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DOI：
10.1126/science.277.5322.112
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发表时间：
1997-07-04
期刊：
影响因子：
56.9
通讯作者：
Leibowitch, J
中科院分区：
文献类型：
--
作者：
Autran, B;Carcelain, G;Leibowitch, J
高效抗逆转录病毒疗法（HAART）增加CD4（+）细胞数量，但其纠正人类免疫缺陷病毒（HIV）诱导的免疫缺陷的能力仍然未知。HAART后证明了三相T细胞重建，其中：（i）记忆性CD4（+）细胞的早期上升，（ii）与逆转录病毒活性降低相关的T细胞活化减少以及CD4（+）T细胞对回忆抗原的反应性提高，以及（iii）“幼稚”CD4（+）淋巴细胞的晚期上升，而CD8（+）T细胞下降，然而，而不需要这些参数的完全标准化。因此，降低HIV载量可以逆转HIV驱动的活化和晚期HIV感染患者的CD4（+）T细胞缺陷。
Highly active antiretroviral therapy (HAART) increases CD4(+) cell numbers, but its ability to correct the human immunodeficiency virus (HIV)-induced immune deficiency remains unknown. A three-phase T cell reconstitution was demonstrated after HAART, with: (i) an early rise of memory CD4(+) cells, (ii) a reduction in T cell activation correlated to the decreasing retroviral activity together with an improved CD4(+) T cell reactivity to recall antigens, and (iii) a late rise of ''naive'' CD4(+) lymphocytes while CD8(+) T cells declined, however, without complete normalization of these parameters. Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients.