HOXA13 promotes liver regeneration through regulation of BMP-7
HOXA13 promotes liver regeneration through regulation of BMP-7
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DOI：
10.1016/j.bbrc.2022.07.018
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发表时间：
2022-07-19
影响因子：
3.1
通讯作者：
Yang, Changqing
中科院分区：
文献类型：
--
作者：
Cui, Beiyong;Yang, Liu;Yang, Changqing
深入了解肝再生可以促进肝损伤和肝衰竭治疗的发展。HOXA 13是同源异型盒超家族成员之一，在肿瘤的发生、发展中起着重要的调控作用。然而，HOXA 13在肝再生中的确切作用仍不清楚。在这项研究中，我们证实HOXA 13促进肝细胞增殖在体内和体外。HOXA 13在肝再生过程中上调，并且其过表达进一步加速肝细胞增殖和肝再生过程中的肝功能恢复。此外，我们发现HOXA 13通过上调骨形态发生蛋白-7（BMP-7）mRNA促进肝细胞增殖和肝再生。这些发现为肝衰竭的治疗提供了一个新的潜在靶点。(C)2022年，任作家。爱思唯尔公司出版
In-depth knowledge of liver regeneration could facilitate the development of therapies for liver injury and liver failure. As a member of the homeobox superfamily, HOXA13 plays an important role in regulating tumorigenesis and development. However, the exact role of HOXA13 in liver regeneration remains unclear. In this study, we confirmed that HOXA13 promotes hepatocyte proliferation both in vivo and in vitro. HOXA13 was upregulated during liver regeneration, and its overexpression further accelerated hepatocyte proliferation and liver function recovery during liver regeneration. Furthermore, we found that HOXA13 promoted hepatocyte proliferation and liver regeneration by upregulating bone morphogenetic protein-7 (BMP-7) mRNA. These findings provide a new potential target for the treatment of liver failure. (C) 2022 The Authors. Published by Elsevier Inc.